Scientist/Sr Scientist - Immunology/Cancer Biology

Monte Rosa Therapeutics Boston , MA 02108

Posted 2 weeks ago

Scientist/Sr Scientist Immunology/Cancer BiologyLocation:Cambridge, MA

Job Code SCIIOB-20-2021

We are seeking a highly motivated and enthusiastic scientist to support Monte Rosa Tx effort to identify small molecule glue degraders in different disease areas such as cancer and autoimmune/inflammatory diseases. In this position within the Target Biology and Translational Research group, the candidate will provide scientific insight for the identification and validation of targets to support indication selection and early clinical development of novel molecular glue degraders. This energetic and self-motivated PhD scientist to join a team of scientists working towards discovery of unique molecular glue degraders for the treatment of targeted patient populations. The candidate will be a highly creative immunologist or cancer biologist with a strong desire to succeed at the highest level.

Principal Duties and Responsibilities

Independently design, execute and interpret cell-based experiments to optimize compound selection and explore therapeutic potential of drug targets

Design and develop cell and molecular assays to define mechanism of action for compounds, identify pharmacodynamic assays for utility in pre-clinical and clinical setting and test patient selection strategies

Identify pharmacodynamic assays for utility in pre-clinical and clinical setting; define PK/PD/efficacy relationships and test patient selection strategies

Utilize literature and internal genomics data sets to design and test hypothesis for drug targets

Interpret, present and report research findings at internal meetings and external scientific conferences


Job Qualifications:

  • Ph.D in immunology, cell/molecular biology, or genetics with 3-5 years industry experience in oncology drug discovery/translational research
  • Expertise in multi-parameter flow cytometry (CytoFLEX experience preferred)
  • Strong technical experience in primary immune cell assays
  • Strong understanding of the hematopoietic system
  • Experience with small molecule-based therapies desired
  • Experience using in vitro / vivo oncology models for drug discovery and translational research
  • Proven track record of striving for high level innovation and scientific excellence
  • Excellent time management skills and flexibility to accommodate to rapidly changing priorities and deadlines
  • Ability to work in a team-based and cross-functional environment
  • Excellent oral, written communication and record keeping skills
icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Senior Scientist Chemical Biology Chemistry

Merck & Co., Inc.

Posted 4 days ago

VIEW JOBS 7/22/2021 12:00:00 AM 2021-10-20T00:00 Job Description Become a part of the cutting edge and highly innovative Chemical Biology and Discovery Chemistry departments. Using robust scientific methodology, bleeding edge chemistry, and state-of-the-art instrumentation and automation, we collaborate to discover the next medical breakthrough. To achieve our goal, we focus on delivering novel mechanisms into our pipeline, expanding druggable space, and the pursuit of detailed knowledge of the mechanism of action for our key pipeline assets. We partner with multiple functional groups to complement capabilities, accelerate discoveries, and advance the best drug candidates into the clinic for significant unmet medical needs. Passion for thinking outside the box is critical in Chemical Biology as a field and to the success of enabling drug discovery programs. We are therefore seeking a highly motivated Senior Scientist to join the Chemical Biology group in the Discovery Chemistry organization within our company's Research Laboratories. The successful candidate will work closely with scientists in Chemical Biology (comprising chemistry, proteomics, and cell pharmacology) as well as colleagues in Discovery Chemistry, Quantitative Biosciences, Genetics and Biomarker Sciences, and Therapeutic Area Biology. * Become part of a creative and flexible team; collaborate and work closely with other scientists. * Contribute to project strategy, experimental design, execution, analysis, and interpretation of experiments. * Collaborate with Oncology, Immunology, Cardiovascular and Metabolic Diseases, Neuroscience and Infectious Diseases discovery teams to develop and execute on Chemical Biology partnered programs. * Contribute to the development of technology builds that further enable the Chemical Biology vision and mission. * Establish strong relationships within highly collaborative, multidisciplinary teams to effectively drive drug discovery initiatives. * Function and communicate effectively in a highly productive multi-disciplinary environment. Preferred Experience and Skills: * Independent synthetic chemistry * Hands-on exposure to cell culture and experimental pharmacology * Have a good understanding of biology concepts and chemical application to solve biological problems * Experience in one or more of the following: * Mechanistic studies of drug action or drug target ID * Novel chemical probe development * Targeted protein degradation * CRISPR genome editing * Live cell imaging or other novel cellular assays * Drugging/targeting RNA with small molecules Required Experience: * PhD or equivalent in Chemical Biology or a related discipline (MS W/3+ yrs, BS w/5+ yrs working experience in a pharma, biotech or academic setting) * A track record of achievement in independently designing and executing experiments is required * Highly self-motivated, creative, and critical thinking to solve complex technical and scientific problems with excellent attention to detail * Strong organizational and communication (oral and written) skills * Robust publication record * Possess exemplary analytical skills * Ability to work independently yet team-oriented and able to build strong relationships in highly collaborative, multidisciplinary teams to effectively drive early drug discovery initiatives * Capable of prioritizing deliverables among multiple simultaneous projects We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. Who we are … We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world. What we look for … In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. NOTICE FOR INTERNAL APPLICANTS In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions. If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor. Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process. For more information about personal rights under Equal Employment Opportunity, visit: EEOC Poster EEOC GINA Supplement OFCCP EEO Supplement Pay Transparency Nondiscrimination We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace. Search Firm Representatives Please Read Carefully Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Regular Relocation: Domestic VISA Sponsorship: Yes Travel Requirements: Flexible Work Arrangements: Shift: Valid Driving License: Hazardous Material(s): Number of Openings: 2 Merck & Co., Inc. Boston MA

Scientist/Sr Scientist - Immunology/Cancer Biology

Monte Rosa Therapeutics