Scientist/Senior Scientist, Protein Analytics

About the Company

Hillstar Bio, is a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue-chip investors. Our passionate team of drug developers is based in Boston’s Seaport neighborhood. 

Hillstar is advancing a portfolio of programs against autoimmune diseases with unmet or underserved medical needs. Its lead program is an antibody designed to selectively target a root cause of Cold Agglutinin Disease (CAD) and other autoimmune diseases. CAD is a chronic, rare (incidence 15/million) but debilitating condition with high morbidity (anemia, fatigue, cold-induced circulatory symptoms). Existing treatment options for CAD have limited effectiveness, carry considerable safety risks, and fail to address key disease symptoms in a large proportion of patients, leading to significant chronic morbidity and excess mortality. By bringing this new precision modality to patients, Hillstar aims to improve on safety and efficacy, as well as durability of response, setting a new gold standard for the management of CAD, and other serious autoimmune conditions with a common biological origin.

Job Description

Join Hillstar Bio as a protein analytics leader performing antibody characterization, developability assessment, pre-formulation and DS/DP releasing assays, and working with a skilled team towards achieving our first IND milestone. Establish platforms of antibody characterization, developability assessment, formulation, protein QC and DS/DP specification. Develop and delineate distinctive protein analytics strategies of programs by corroboration with antibody discovery, immunology and CMC groups.

This pivotal role offers opportunities to shape our company culture, contribute to organization growth, and make a significant impact on treatment of autoimmune disease to benefit patients. We seek an enthusiastic scientist with extensive hands-on experience, broad knowledge in a variety of advanced biophysical characterization techniques, and strong cross-functional collaborative mindset in a fast-paced environment.

Key duties and accountability

Perform reagent QC, biophysical and biochemical protein characterization and antibody developability/manufacturability assessment in all stages of antibody development.

Manage analytical method development and validation under ICH guideline.

Lead development candidate (DC) nomination.

Identify, evaluate, and implement new and existing technologies to improve protein characterization capabilities, throughput, and quality.

Monitor, maintain, and calibrate laboratory instruments and equipment.

Requirements

Qualifications

MS or PhD in Biochemistry, Biology, or a related field with at least 5+ years (MS) or 2+ years (PhD) of relevant industrial experience in protein analytics and characterization

Strong hands-on experience in protein biophysical characterization techniques such as DSF, DSC, SEC-MALS, DLS, Octet, CE, icIEF, HPLC-based assays (SEC, HIC, IEX, etc.)

Experience in CMC management of analytical method validation.

Experience with Flow cytometry is a plus.

Ability to establish and troubleshoot experiments.

Ability to thrive in a highly collaborative, fast-paced, team-oriented environment with colleagues from diverse disciplines.

Benefits

Compensation and Benefits

Hillstar Bio offers a competitive compensation and benefits package, including a competitive salary, equity, and a comprehensive benefits package.

Additional Information

This is a full-time position located in our Boston, MA office. We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.