Pfizer's Rare Disease Research Unit (RDRU) focuses on developing drugs for treating rare diseases. The Gene Therapy Translational Research group is part of the RDRU focused on AAV- mediated gene transfer approaches while developing treatments for rare genetically defined diseases that focus on the CNS, neuromuscular, and liver (systemic and metabolic) therapeutic areas. This bench Scientist will be part of a larger interdisciplinary team and contribute to generating various viral vector constructs to advance Pfizer's gene therapy programs. The role requires extensive knowledge and experience in creating synthetic genes, DNA analysis, recombinant protein expression, cloning, quantitative PCR assays, viral potency and quantification assays, fluorescent microscopy, and cell culture techniques. In addition, experience in working on in vivo experiments is desirable. This role also requires contribution to developing and performing cell based and biochemical assays to characterize viral vectors and the encoded transgene products. The bench Scientist will be required to work independently and have a deep knowledge of various molecular biology techniques and assays, in vivo studies, viral vector biology, and strong scientific judgment in making decisions within the area of technical expertise. The role will also involve developing, implementing and running assays in support of different portfolio program.
Design, synthesize, clone and characterize synthetic DNA sequences
Perform molecular and cell based assays to characterize AAV gene therapy vectors.
Perform biochemical assays to characterize AAV vectors both in vitro and in vivo.
Partner with colleagues working on Gene Therapy projects within the rare disease and other organizations.
Analyze and present the data to colleagues within and outside of the research unit.
Constantly review scientific literature and present novel ideas towards progressing goals
Ph.D. or Masters Degree in the life sciences with 2+ years of relevant experience or Bachelor's Degree with 5+ years of relevant experience in the field of recombinant AAV vectors.
Prior experience with characterization of viral vectors using cell and molecular biology techniques required. Prior experience with rAAV is highly desired, including work with small or large animal models.
Evidence of scientific accomplishments in the form of publications and presentations.
Evidence of experience working in cross-disciplinary teams.
Exceptional communication and presentation skills and demonstrated ability to work effectively as part of a team.
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N (Other) (United States of America)
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