Scientist/ Senior Scientist, In Vivo Pharmacology

KSQ Therapeutics Cambridge , MA 02139

Posted 1 week ago

About KSQ Therapeutics

At KSQ Therapeutics, we seek to understand the role of every human gene in each disease, each tissue, and each cell that we study. This comprehensive approach has resulted in a massive, experimentally derived dataset that we have found to be remarkably predictive of past successes and failures in oncology and immuno-oncology product development. Utilizing this approach, we also identified a number of opportunities for the development of new medicines. As a result, we have aggressively invested in these distinct, highly validated pathways for new drug development with the expectation that the medicines we create may become the next breakthrough products for patients.

Founded in late 2015, KSQ is a preclinical-stage biotech in Kendall Square that has rapidly advanced the field of CRISPR-enabled functional genomics, from in vitro cell autonomous screens to more complex genome-scale screens of immune cells in vivo. The company has expanded the scope of its technology to include multiple cell types and to unlock areas beyond oncology. KSQ is led by a team of accomplished industry experts in drug discovery and development. We maintain a lively and inquisitive environment in the heart of the vibrant Kendall Square neighborhood.

Position summary:

We seek a motivated and team-oriented individual who will be a key contributor to the overall success of KSQs in vivo pharmacology department. The successful candidate will contribute hands-on technical expertise for all aspects of in vivo pharmacology including tumor xenograft, MTD, and PK/PD studies to help evaluate the pharmacology of novel therapeutic agents.


Requirements & Qualifications:

Requires a B.S. with 3-5+ years of experience in pharmacology in an industry setting or MSc with 1-3+ years of drug discovery experience in the biotechnology or pharmaceutical industry with the following:

  • Demonstrated experience with independent organization and execution of in vivo studies to evaluate tolerability, efficacy and mechanism of action of therapeutic agents.
  • Experience in oncology in vivo models including cell culture, compound preparation, and administration (e.g. i.v., s.c., p.o.), syngeneic, CDX, PDX, and orthotopic implantation and measurement, and blood sampling and ex vivo sample preparation.
  • 1-3 years of Flow cytometry experience is required.
  • Experience in developing and executing ex vivo assays to investigate target and/or therapeutic MOA by flow cytometry, RNA-seq, DNA-NGS is recommended.
  • Experience managing pharmacology studies at contract research organizations (CROs) is desirable.
  • Excellent verbal and written communication and interpersonal skills for participating across functional groups and externally.
  • The successful candidate will:

  • Independently execute on a wide variety of in vivo techniques across multiple projects with delivery of high-quality data.
  • Effectively perform data entry and analysis from all studies in a timely manner while communicating experimental results to manager and a wider audience when required.
  • Work collaboratively within department and across departments to effectively achieve project goals and timelines.
  • Represent in vivo pharmacology on drug discovery teams.
  • Understand and implement applicable regulations around animal care/safety/handling.
  • Be high energy and open-minded while working in a collaborative, innovative and fun environment.
  • icon no score

    See how you match
    to the job

    Find your dream job anywhere
    with the LiveCareer app.
    Mobile App Icon
    Download the
    LiveCareer app and find
    your dream job anywhere
    App Store Icon Google Play Icon

    Boost your job search productivity with our
    free Chrome Extension!

    lc_apply_tool GET EXTENSION

    Similar Jobs

    Want to see jobs matched to your resume? Upload One Now! Remove
    Senior Research Associate In Vivo Pharmacology

    Editas Medicine

    Posted Yesterday

    VIEW JOBS 10/26/2020 12:00:00 AM 2021-01-24T00:00 <p>What if you could repair broken genes? That is the question we ask ourselves at Editas Medicine. We’re focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for many diseases.</p> <p>We’re looking for talented, dedicated, passionate people to join our team and help us pioneer this field and do big, bold things that have never been achieved before.</p> <p>Are you full of hope, possibilities, and a belief that, working together, we can truly revolutionize the development of medicines to help patients around the world? If the answer is yes, then Editas Medicine is the place for you.</p> <p>Editas is seeking a highly motivated Senior Research Associate/Principal Research Associate to join our in vivo pharmacology group. The candidate will be responsible for conducting preclinical animal studies to support the development of gene-editing based therapies in ophthalmology. The successful candidate will be part of a dynamic team and will interact with the discovery, process development groups, as well as contract research organizations. The successful candidate should demonstrate strong work ethics and ability to work in a fast-paced and highly demanding work environment.</p> <p><strong>Key Responsibilities</strong></p> <ul> <li>Perform molecular biology work such as DNA and RNA extraction, qPCR, ddPCR,western blot, and ELISA.</li> <li>Perform intraperitoneal and intraocular injections in mice, monitor animal health, collect tissue samples, perform anesthesia and necropsies.</li> <li>Properly handle viral vectors such as AAV.</li> <li>Assist in vivo studies in ophthalmology disease areas. </li> <li>Design and execute molecular-based assays to understand in-vivo therapeutic activity, efficacy and PK/PD properties. </li> <li>Optimize and refine in vivo procedures and molecular techniques to expedite and increase quality of data generation. </li> <li>Properly handle preclinical biohazardous samples to ensure personal and lab safety</li> <li>Analyze and present data within the organization.</li> <li>Share responsibility in maintaining lab equipment and reagent inventory.</li> <li>Maintain lab notebook in a timely fashion.</li> <li>Interact with vendors, CROs, collaborators and internal teams for various functions.</li> <li>Generate technical documents, SOPs, study reports and other forms of documentation for IND-enabling activities and assay development. </li> <li>Ensure quality handling of preclinical samples, rigorous validation of preclinical materials and assays to generate high-quality data.</li> <li>Experience with NCS</li> </ul><p><strong>Requirements</strong></p><ul> <li>BS in Biology related field of study with 5+ years of hands-on experience in academic or industry setting or MS in Biology related field of study with 2+ years of hands-on experience in academic or industry setting.</li> <li>Self-motivated and detail-oriented. Quick learner and willing to be trained in new techniques.</li> <li>Committed to drive assignments to completion, well-organized and excellent in multi-tasking.</li> <li>Excellent oral and written communication skills.</li> <li>Excellent interpersonal skill and excel in a team environment</li> <li>Experience with assay design and validation across multiple molecular platforms</li> <li>Preference for individuals with demonstrated knowledge of molecular biology techniques and in vivo techniques.</li> <li>Hands-on experience with subretinal and intraocular injection in mice and In vivo and post-mortem analysis of retinal gene therapy outcome (OCT, funduscopy, ERGs, imaging). </li> <li>Result-driven with excellent attention to details and ability to independently execute protocols </li> <li>Experience with troubleshooting assays, including consulting available literature</li> <li>Ability to think critically, extract conclusions from data sets to inform future studies, assess any flaws with data set and take action to address such issues through optimization and refinement of assays and protocols </li> </ul> Editas Medicine Cambridge MA

    Scientist/ Senior Scientist, In Vivo Pharmacology

    KSQ Therapeutics