Scientist, Process Research (Portland)

Vir Biotechnology, Inc. Portland , OR 97228

Posted 5 days ago

Vir Biotechnology is a clinical-stage immunology company focused on combining immunologic insights with cutting-edge technologies to treat and prevent serious infectious diseases. Vir has assembled four technology platforms that are designed to stimulate and enhance the immune system by exploiting critical observations of natural immune processes. Our current development pipeline consists of five product candidates targeting hepatitis B virus, influenza A, human immunodeficiency virus and tuberculosis.

Vir Biotechnology is seeking an experienced Scientist to join a fast-paced interdisciplinary team focused on process improvement. The candidate will be responsible for laboratory process research and process development related to our CMV vector platform. Activities will include method optimization, material qualification, document authorship, and process qualification. This individual will work with third parties when necessary (e.g., suppliers and CMOs) to support process development, transfer and validation as needed. The position will provide cross-functional support to quality control/assurance, analytical development, process analytics, and other functions.

The successful candidate will play an integral role in designing and conducting laboratory studies focused on methods that improve production, reduce costs, and streamline workflow of the CMV vaccine vector platform. This individual will ensure that studies, tests and procedures performed in the laboratory follow quality procedures for all aspects of work.

RESPONSIBILITIES

  • Conduct laboratory work involved in the production, growth, and evaluation of viral vector vaccine candidates.

  • Apply process engineering/development knowledge to scale-up and scale-out of bioprocesses to enable multi-site process development and production of novel therapeutic vaccines.

  • Provide input into the strategy and design of research projects to improve vaccine production process.

  • Review and suggest new approaches and laboratory techniques.

  • Explore upstream culture methods/conditions to improve cell growth conditions and virus yield.

  • Optimize downstream purification and concentration methods for improved yield and stability.

  • Maintain and evaluate mammalian host cell cultures for growth conditions, viral vector production and purification, residual host cell protein, and residual host cell DNA.

  • Assist in studies to optimize the ability to manufacture CMV-vectored vaccines, such as evaluation of alternative transfection systems, host or vector gene deletions or insertions, viral culture yield, systems for viral growth, etc.

  • Evaluate and perform analytic assays to determine the quality, yield, stability, etc. of specific candidates or of specific manufacturing process conditions.

  • Work under GLP-like conditions, with the appropriate requisite training, documentation, and attention to following defined operating procedures and work flows.

  • Ensure that the laboratory and activities comply with GLP-like standards and that all results produced are reviewed and represented appropriately.

  • Maintain reagent and supply inventory, conduct laboratory cleaning, and equipment maintenance.

  • Participate in the development and conduct of laboratory meetings.

  • Perform other duties as required.

QUALIFICATIONS AND EXPERIENCE

  • At least 6 years of relevant work experience, with demonstrated experience in laboratory bench work with a focus in cell culture and virus culture, and purification.

  • Expertise in scaled aseptic bioprocess operations with closed culture systems and cell processing equipment and techniques (HYPERStack, CellSTACK, Xpansion, microcarrier culture, bulk harvest and purification, tangential flow filtration, and cryopreservation processes.

  • Proficient in conducting research using a variety of cell based and molecular methods; e.g., ELISA, Western blot, viral growth curves, viral titers, transfections, PCR, DNA sequence interpretation.

  • Excellent written and communication skills; ability to understand and communicate scientific information.

  • A self-starter with the ability to work in a fast-paced environment and adapt quickly to changing needs and priorities; proven ability to prioritize and manage multiple tasks simultaneously.

  • Ability to work under tight timelines and effectively communicate to internal stakeholders and external partners.

  • Demonstrated history of strong hands-on ability, problem solving, and independent experimental design and execution.

EDUCATION

  • MS/Ph.D. and 6+ years in the biological sciences, biochemistry or experience in biotech and/or bioengineering field.

  • Understanding and experience with experimental optimization, design, and validation in bioprocess research.

  • Experience operating in early stage clinical or commercial environments.

VIR is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual's race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.

The Human Resources team manages the recruitment and employment process for Vir. Unsolicited resumes sent to Vir from recruiters do not constitute any type of relationship between the recruiter and Vir and do not obligate Vir to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.


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Scientist, Process Research (Portland)

Vir Biotechnology, Inc.