The Fluid Biomarker group, within the Biomarker Department and part of Clinical Sciences is seeking a highly independent and motivated scientist to join a dynamic team engaged in the discovery and progression of novel biomarkers from research to implementation in preclinical studies and/or clinical trials. Responsibilities include identification, evaluation, characterization, and development of relevant fluid biomarkers in support of programs across Biogen's Multiple sclerosis (MS) portfolio, possibly also supporting the emerging immunology pipeline. The successful candidate will be capable of multitasking, setting goals, priorities, and planning timelines. In addition, effective strategic thinking, impactful communication, and collaboration skills are crucial.
Design and effectively communicate program stage appropriate biomarker strategies to the team and lead execution.
Per the need(s) of the program, identify, strategically develop, and deploy impactful target engagement, disease activity and/or pharmacodynamic biomarkers to enable program progression and assist in go/no-go decisions.
Effectively use Immuno-based platforms (ELISAs, ELLA, SIMOA, MSD U-plex/S-plex) to develop and qualify fit-for-purpose biomarker assays in house or provide scientific oversight at appropriate CROs.
Oversee accurate representation and interpretation of biomarker data in all relevant documents/internal or external publications (clinical study protocols, clinical study reports, posters, manuscripts)
Build partnerships with colleagues in research, biostats, medical, clinical pharmacology, safety for effective integration of biomarker strategies in the program's development plan.
Establish and manage partnerships with both internal research colleagues as well as external research collaborations to support identification of novel biomarkers.
1.Experience in the development and qualification of biomarker assays in the preclinical and clinical setting with an emphasis on fit-for-purpose qualification for the specific context in which biomarker data is intended to be used and /or will be impactful.
2.Proven experience with high-sensitivity immunoassay platforms, including novel assay development, troubleshooting and implementation along with either experience in or willingness to learn additional technologies (e.g. flow cytometry).
3.Direct expertise and knowledge of Multiple sclerosis, Immunology and/or neurodegenerative diseases preferred.
4.Ability to quickly absorb new information and develop an understanding of the relevant biology, pathway, mechanism of action and multiple sclerosis disease indication in general.
5.Must be a highly flexible, results oriented, independent self-starter with effective communication skills and leadership presence who enjoys working in a fast-paced dynamic environment and enjoys asking the right questions.
PhD in biological sciences or Neuroscience with at least 5+ years post-PhD experience including at least 3+ years industry experience leading biomarker development.
All of your information will be kept confidential according to EEO guidelines.