Scientist, Ipsc Discovery Biology

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

Scientist, iPSC, Discovery Biology

Responsibilities

• Generate in vitro cell-based model systems using pluripotent stem cells differentiated into cell types relevant to neurodegeneration, including neurons, microglia and astrocytes

• Implement methods of genetic engineering in pluripotent stem cells for downstream applications in therapeutic screening and model development

• Build novel iPSC-based assays using genetically encoded reporters to improve mechanistic understanding of how genetic risk factors influence biology in distinct cell types

• Participate in the development of sophisticated in vitro model systems such as organoids and combination cultures

• Work across interdisciplinary teams that are seeking to understand the basic biology of neurodegeneration

• Perform experiments, make detailed scientific observations, analyze data, interpret and present results

• Publication of work in collaboration with other scientists is encouraged

Requirements

• PhD or M.S (+3 yrs relevant work experience) in Cell Biology, Developmental Biology, Neurobiology, or related field

• Expertise in engineering iPSCs using CRISPR/Cas9 and/or lentiviral overexpression or other mechanisms

• Experience in mammalian cell culture, including sophisticated culture models involving stem cell maintenance and multi-lineage differentiation

• Experience with isolation, characterization, and culture of sorted cells, including use of FACS-based sorting techniques

• Excellent analytical and critical thinking skills

• Strong oral and written communication skills

• Some weekend work may be required

• Desire to work in a highly collaborative environment

Salary Range: $000,000.00 - $000,000.00. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers

Salary Range: 93,760.00 to 100,905.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers

This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

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