Scientist, In Vivo Immunology

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At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we've invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK's long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.

The Scientist in the in vivo immunology team will support or may serve as the preclinical in vivo study lead and will support the project team in spearheading GSK's innovation of novel viral vaccines and platform programs. You will have the opportunity to work on the in vivo efforts on multiple viral vaccine programs and platforms within GSK and with external partners in a collaborative and matrix team. You will assist in the design and writing of in vivo study protocols, coordinate and initiate preclinical studies, conduct and analyze experimental results pertaining to the understanding of cellular mediated immune response and humoral immune response from novel vaccine candidates, formulations, and RNA platforms.

Key Responsibilities:

This role will provide you with the opportunity to lead key activities and to progress your career based on performance. The responsibilities include the following:

• Help design, plan, conduct, coordinate, monitor, and analyze in vivo murine studies for vaccine and platform programs.
• Implement and ensure adherence to GSK and regulatory requirements for compliance with IACUC guidelines through writing and reviewing in vivo study protocols and participating in the independent scientific review committee.
• Conduct dosing, IVIS imaging, necropsy, and tissue harvest from animal studies
• Perform experiments characterizing cell-mediated immune response for preclinical immunogenicity or challenge studies using flow cytometry, ELISPOT assays and others.
• Analyze experimental date and document them in detail using an electronic notebook
• As a preclinical in vivo study lead, you will work in a matrix team to support the identification of novel vaccine candidates and support platform development.
• Prepare and document study protocols and final reports for projects as an author.
• Contribute to patent filing, IND submissions, and scientific publications.
• Present study plans and results at project meetings.
• Develop new experimental techniques based on project needs.

The successful applicant will spend 2-6 months within the first year in Rockville, MD to support and guarantee a smooth transition of methods and know-how to the new laboratories in Cambridge, MA

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

·Ph.D., M.S., or B.S. degree in immunology or a related field. The required post-graduate work experience is 0-1 years or more for a Ph.D., 4 years or more for an M.S., and 8 years or more for a B.S.

·One or more years of experience in conducting in vivo animal studies within the fields of vaccines, infectious diseases, or immunology.

• One or more years of experience in small rodent handling and drug administration, in-study blood sampling, necropsy, tissue harvest, and processing.
• One or more years of experience in designing, executing, and analyzing cell-mediated immune response readouts using conventional or spectral flow cytometry.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• A collaborative team player with strong interpersonal skills to work with diverse groups within the organization.
• Excellent communication and writing skills.
• Detail-oriented with the agility to balance multiple projects.
• Extremely organized with experience in documentation of study protocols and reports.
• Experience with immune-response related readout methods such as ELISA, ELISPOT, Luminex, and qPCR methodologies.

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Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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