Kriya Therapeutics Durham , NC 27701
Posted 2 weeks ago
Who You Are
The individual hired into this role will participate in a research group focused on investigative Immunology and the development and method transfer and/or in house implementation of Immunological assays that support Kriya's current and exploratory programs. This includes the development, optimization, potential qualification, and execution of assays in support of non-clinical and clinical development of AAV-based products or evaluation of novel models and assays designed to evaluate immunogenicity or pharmacokinetic/pharmacodynamic profiles. Clinical and/or non-clinical sample analysis experience or clinical biomarker assay development/translational sciences experience is required. Experience in one or more immunologic assay type including but not limited to experience in ex vivo cell based assays and evaluation of immune responses or marker expression by either flow cytometry, immunocytochemistry, or immunohistochemistry is required. Additionally, this role will oversee a small team of scientists that will develop methods and data to support immunology-based questions or identify potential biomarkers in support of Kriya's pipeline. The ideal individual for the role will be highly organized with attention to detail and a passion for learning and be highly adaptable. This individual will work closely with other team members to execute the assays and support data analysis and presentation as needed. This role will provide the individual the opportunity to grow and develop while advancing Kriya's pipeline from research into clinical phase development.
How You Contribute
Lead biological project to implement, develop and qualify immunological assays including but not limited to ELISA, MSD, immunocytochemistry, fluorescent microscopy and flow cytometry under direction of project leader.
Conduct non-clinical and clinical sample analysis as directed in support of pharmacology and translational studies to support program stage gate decision making
Help identify or evaluate potential biomarkers in support of Kriya's pipeline targets
Assist and may lead assay transfer to contract research organizations (CROs) and/or other labs in support of nonclinical and/or clinical studies
Perform data analysis using appropriate software (such as SoftMax, Prism, etc.)
Responsible for documentation of all project work in appropriate electronic and/or paper-based laboratory systems
Responsible for reagent sourcing, receipt, storage, inventory and preparation as directed
Responsible for maintenance of laboratory instrumentations as directed
Collaborate with other scientists and routinely present data
Maintenance of updated safety, compliance, and SOP training
Ability to work in a fast-paced team-oriented setting with good communication skills
What You Bring to the Team
Education & Experience
Senior Scientist
Degree in immunology, biochemistry, or relevant discipline plus relevant working experience (years) in a pharmaceutical/biotechnology or CRO laboratory setting:
Bachelor's degree with 12+ years' work experience
Master's degree 10+ years' work experience
PhD degree or equivalent with 7+ years' work experience
Scientist III
Degree in immunology, biochemistry, or relevant discipline plus relevant working experience (years) in a pharmaceutical/biotechnology or CRO laboratory setting:
Bachelor's degree with 10+ years' work experience
Master's degree 8+ years' work experience
PhD degree or equivalent with 5+ years' work experience
Competencies
Hands-on experience in cell-based assay method development, non-clinical or clinical sample analysis, particularly in evaluation of immune responses and biomarker assays
Experience with mammalian cell culture including transduction and transfection of cell lines and primary cells or isolation of cell populations
Must be highly organized with attention to detail
Excellent written and oral communication skills
Highly adaptable to changes and fast-paced setting
Positive attitude with a solutions-based approach to challenges
Experience with mammalian cell culture a must
Experience with neurological, metabolic, and/or ocular in vitro models is preferred
Experience with flow cytometry, immunohistochemistry, fluorescent microscopy, or immunoassays is preferred
Working Conditions and Physical Demands
Work is normally performed: at a desk and laboratory environment
Lifting requirements: Over 20 lbs
Travel requirements: Occasional
Must be willing to work at the bench as well at a desk
About Kriya
Kriya is a biopharmaceutical company whose mission is to develop life-changing gene therapies for diseases affecting millions of patients around the world.
We leverage our proprietary computational engine, in-house manufacturing infrastructure, and integrated design platform to engineer technologies and therapeutics with the potential to transform the treatment of a broad universe of diseases of high unmet need, with a focus on metabolic disorders, neurology, and ophthalmology.
What We Offer
Medical, Dental and Vision with 100% employee premium coverage ∙ Retirement matching ∙ Short and long-term disability benefits ∙ 12 company paid holidays ∙ Generous Time Off ∙ Cyber Safety protection ∙ EAP ∙ Company paid life insurance ∙ Equity ∙ and more!
Kriya is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.
All job requirements in the job description provided indicate the minimum level of knowledge, skills, and/or abilities deemed necessary to perform the job competently. Job descriptions are an overview of the duties, responsibilities, and requirements of the position. Employees may be required to perform other job-related assignments as requested.
Kriya Therapeutics