Scientist I/Ii, Conjugation Chemist

Abbvie, Inc Worcester , MA 01601

Posted 1 week ago

AbbVie Bioresearch Center in Worcester, MA has an opening for a Scientist I/II in Discovery to conduct pre-clinical research and development in the area of antibody drug conjugates (ADCs).

Key Responsibilities Include:

  • Synthesis, purification and characterization of ADCs on mg to gram scale under minimal supervision.

  • Optimization and validation of conjugation protocols and formulation buffers.

  • Optimization of automated techniques for ADC synthesis and purification.

Position will be hired based on level of experience.

  • BS or MS degree with 5-8+ (BS) or 2-5+ (MS) years of experience in Analytical Chemistry, Biochemistry, Chemistry or other relevant discipline.

  • Knowledge and experience in laboratory scale protein purification, employing Hydrophobic Interaction Chromatography (HIC), Size Exclusion Chromatography (SEC), Ion-Exchange (IEX), mixed mode chromatography and affinity chromatography. Experience with GE AKTA FPLC and unicorn software preferred.

  • Previous experience in the discovery and development of Antibody-Drug Conjugates, including hands-on experience with the conjugation and purification process is desired.

  • Hand on experience in analytical techniques including HIC-HPLC, SEC, IEX, RP-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF).

  • This position requires an individual who is self-motivated, enthusiastic, hard-working, detail-oriented, with demonstrated problem solving skills who is able to work in a fast-paced team environment. High-quality written and oral communication skills and the ability to excel in a collaborative environment are essential.

Additional Information

  • AbbVie is an Equal Employment Opportunity employer: At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer, we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.

  • Significant Work Activities and Conditions: Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)

  • Travel: Yes, 5 % of the Time

  • Job Type: Experienced

  • Schedule: Full-time

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VIEW JOBS 4/13/2019 12:00:00 AM 2019-07-12T00:00 AbbVie Bioresearch Center in Worcester, MA has an opening for a Senior Scientist in Discovery to conduct pre-clinical research and development in the area of antibody drug conjugates (ADCs). Key Responsibilities include: * Synthesis, purification and characterization of ADCs on mg to gram scale. * Development and optimization of conjugation protocols utilizing novel chemistries and technologies. * Development and optimization of automated techniques for ADC synthesis and purification. * Collaboration with Therapeutic Area Project Teams, as well as core Chemistry, Protein Science and Process Development teams to expand conjugation capabilities at Abbvie. * PhD in Organic Chemistry/ Biochemistry/Chemical Biology or other relevant discipline with 0-3+ years of relevant experience. * Hands-on experience with generation and characterization of antibody drug conjugates preferably in the area of biotherapeutics. * Proficient in analytical techniques including Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography–mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, and capillary electrophoresis (e.g. reduced and non-reduced CE-SDS, icIEF). * Hands-on experience and knowledge in protein purification using HIC, IEX, SEC and affinity chromatography. Experience with GE AKTA FPLC and unicorn software preferred. * This position requires an individual who is self-motivated, enthusiastic, hard-working, detail-oriented and able to work in a fast-paced team environment with demonstrated problem solving skills. * High-quality written and oral communication skills and the ability to excel in a collaborative environment are essential. Additional Information * AbbVie is an Equal Employment Opportunity employer: At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer, we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic. * Significant Work Activities and Conditions: Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day) * Travel: Yes, 5 % of the Time * Job Type: Experienced * Schedule: Full-time Abbvie, Inc Worcester MA

Scientist I/Ii, Conjugation Chemist

Abbvie, Inc