At CRISPR Therapeutics, we are focused on developing transformative gene-based medicines for serious human diseases.
We are rapidly translating our specific, efficient and versatile CRISPR/Cas9 gene-editing platform into therapies to treat hemoglobinopathies, cancer, diabetes and other diseases
Our multi-disciplinary team of world-class researchers and drug developers works every day to translate our CRISPR/Cas9 technology into breakthrough human therapeutics. Our lead program targeting the blood diseases -thalassemia and sickle cell disease has entered clinical testing, and our immuno-oncology programs, focused on CRISPR/Cas9-edited allogeneic CAR-T cell therapies, have the potential to deliver a new generation of cancer therapies to patients.
Support the development of analytical assays for biochemical and biophysical characterization of AAV, Cas9, guide RNAs and gene edited cells.
Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate.
Support assay qualification and validation activities and interact with CMOs and other vendors, as required.
Cross-functional and highly visible position within Technical Operations group. Position requires active collaboration with research, process development and quality teams.
Provide expertise on multiple techniques to support trouble shooting and enhancing of existing assays.
Support analytical sections of regulatory filings for US, Europe and ROW.
Ph.D. in analytical chemistry, protein biochemistry, chemical engineering or related sciences with 0-4 years of relevant experience in industry, or Ph.D with 4-9+ years of relevant experience.
Demonstrate expertise in development of analytical assays like HPLC, LC-MS, CE or related methods for analysis of conjugated proteins, peptides, nucleic acids and small molecules.
Experience in DLS, MALS, UV-Vis, and other spectroscopic techniques for analysis of biologics, conjugated proteins and small molecules.
Assay development experience for analysis of process- and host- specific residual impurities (small molecule and biologics) is preferred.
Protein biochemistry experience for support of critical reagent generation (expression, purification and labeling of proteins) will be a plus.
Experience with qualifying and validating assays and an understanding of ICH/ FDA guidelines is preferred.
Experience in working with and managing external vendors/ CROs is preferred.
Prior experience of working on characterization of gene therapy products including starting materials is preferred.
Excellent organization skills, able to multi-task in a fast-paced environment with changing priorities. Must be able to work effectively as part of a multi-disciplinary team.
Understanding of statistical tools, such as JMP, DoE, Prism etc. will be a plus.
Track record of completing deliverables within specified timelines and "do-what-it-takes" attitude.
Superb communicationsboth written and oral skills.
Independently motivated, detail oriented and good problem-solving ability.
CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.
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Crispr Therapeutics AG