Scientist I/Ii Analytical Chemistry/ Physico-Chemistry

Crispr Therapeutics AG Cambridge , MA 02138

Posted 10 months ago

Company Overview

At CRISPR Therapeutics, we are focused on developing transformative gene-based medicines for serious human diseases.

We are rapidly translating our specific, efficient and versatile CRISPR/Cas9 gene-editing platform into therapies to treat hemoglobinopathies, cancer, diabetes and other diseases

Our multi-disciplinary team of world-class researchers and drug developers works every day to translate our CRISPR/Cas9 technology into breakthrough human therapeutics. Our lead program targeting the blood diseases -thalassemia and sickle cell disease has entered clinical testing, and our immuno-oncology programs, focused on CRISPR/Cas9-edited allogeneic CAR-T cell therapies, have the potential to deliver a new generation of cancer therapies to patients.

Job Summary

  • Support the development of analytical assays for biochemical and biophysical characterization of AAV, Cas9, guide RNAs and gene edited cells.

  • Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate.

  • Support assay qualification and validation activities and interact with CMOs and other vendors, as required.

  • Cross-functional and highly visible position within Technical Operations group. Position requires active collaboration with research, process development and quality teams.

  • Provide expertise on multiple techniques to support trouble shooting and enhancing of existing assays.

  • Support analytical sections of regulatory filings for US, Europe and ROW.

About you:

  • Ph.D. in analytical chemistry, protein biochemistry, chemical engineering or related sciences with 0-4 years of relevant experience in industry, or Ph.D with 4-9+ years of relevant experience.

  • Demonstrate expertise in development of analytical assays like HPLC, LC-MS, CE or related methods for analysis of conjugated proteins, peptides, nucleic acids and small molecules.

  • Experience in DLS, MALS, UV-Vis, and other spectroscopic techniques for analysis of biologics, conjugated proteins and small molecules.

  • Assay development experience for analysis of process- and host- specific residual impurities (small molecule and biologics) is preferred.

  • Protein biochemistry experience for support of critical reagent generation (expression, purification and labeling of proteins) will be a plus.

  • Experience with qualifying and validating assays and an understanding of ICH/ FDA guidelines is preferred.

  • Experience in working with and managing external vendors/ CROs is preferred.

  • Prior experience of working on characterization of gene therapy products including starting materials is preferred.

  • Excellent organization skills, able to multi-task in a fast-paced environment with changing priorities. Must be able to work effectively as part of a multi-disciplinary team.

  • Understanding of statistical tools, such as JMP, DoE, Prism etc. will be a plus.

  • Track record of completing deliverables within specified timelines and "do-what-it-takes" attitude.

  • Superb communicationsboth written and oral skills.

  • Independently motivated, detail oriented and good problem-solving ability.

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

To view our Privacy Statement, please click the following link:

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Scientist I/Ii Analytical Chemistry/ Physico-Chemistry

Crispr Therapeutics AG