Scientist II, Immuno-Oncology (Solid Tumor)

Position: Scientist II, Immuno-Oncology (Solid Tumor) Location: Boston, MA

Job Id: R091-R # of Openings: 1

We seek an energetic and motivated Scientist II to join our Immuno-Oncology team, which is aiming to redirect the immune system towards tumors by engineering hematopoietic cells in vivo. In this role, you will have the opportunity to explore novel immune cell engineering strategies, with an initial focus on monocytes and macrophages, by in vivo delivery of CARs and other immunomodulatory transgenes to reprogram the immunosuppressive tumor microenvironment. You will be expected to have a strong commitment to experimental work and be an independent thinker that can communicate and interact effectively across various disciplines.

You will join a team of scientists dedicated to moving a novel immunotherapy drug candidate into the clinic. Join us and be part of building a company revolutionizing the reach and access of the curative power of genomic medicines for patients with serious diseases.

Responsibilities:

• Recommend and develop suitable syngeneic and xenogeneic tumor models and endpoint assays to interrogate novel immune cell engineering strategies, including in vivo CAR delivery

• Drive collaborative research activities to design and test candidate CAR constructs for expression and functionality in vivo, including measuring phenotypic polarization, tumor infiltration, impact on tumor microenvironment, and anti-tumor activity

• Maintain familiarity with current literature and developments in the field to guide the research project and make recommendations to the team

• Maintain laboratory records, procedures and summaries of data

• Perform laboratory experiments, report data, and suggest future work to management and project teams

Qualifications:

Required:

• A PhD with a minimum of two years of relevant post-PhD work, or equivalent combination of relevant education and laboratory experience in biological sciences, preferably in Immunology, Biology or Cell Biology

• Expertise with preclinical animal models to study novel immunotherapies, including immuno-oncology

• Knowledge of biology and functional properties of various immune cell populations

• Proven ability to work independently and design experiments, trouble shoot, interpret and report data back to teams

• Experience developing content for presentations, electronic notebooks, and scientific reports

Preferred:

• Prior experience working in a collaborative industry environment

• Experience with preclinical animal models for cellular therapies in oncology

• Expertise in myeloid cell biology

• Experience with typical in vitro methodologies to measure immune cell function, including flow cytometry, ELISA, real-time microscopy, etc.

About Ensoma:

Ensoma is a place where you can ask the big questions. We look at gene therapy today and ask: What if we could eliminate the patient burden? What if we could treat diseases that affect millions? What if we could treat people anywhere around the world?

Ensoma was founded to answer these questions through our Engenious platform that can transform the hematopoietic (blood & immune) system with a single treatment. Our Engenious gene therapy platform is the first to precisely engineer any or all hematopoietic and immune cells with a one-time, off-the-shelf in vivo treatment. Engenious therapies have an unmatched capacity to deliver all modern genetic modification tools and set a new standard for versatile cell programming and control across a range of complex diseases. We believe the future of medicine lies within us - and this bigger, bolder vision for gene therapy needs incredible people to make it a reality.

For our team, realizing this vision is personal. Founded and guided by leaders drawn from the top of the cell and gene therapy field, we feel an urgency and passion for our work driven by its potential global impact.

A meeting at Ensoma is a space where curiosity, trust, authenticity, problem-solving and professional development are celebrated. A career at Ensoma is an opportunity to be part of the team building the future of medicine.

Ensoma is a 5AM Portfolio company supported by top-tier investors, strategic partners, and a passionate team committed to a bold global vision for genomic medicines. Ensoma is headquartered in Boston, Massachusetts and has operations in Copenhagen, Demark. For more information, please visit www.ensoma.com.