Scientist I, Research Analytics

Editas Medicine Cambridge , MA 02138

Posted 2 months ago

Apply

This Job is not relevant Tell us why

What if you could repair broken genes? That is the question we ask ourselves at Editas Medicine. Were focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for many diseases.

Were looking for talented, dedicated, passionate people to join our team and help us pioneer this field and do big, bold things that have never been achieved before.

Are you full of hope, possibilities, and a belief that, working together, we can truly revolutionize the development of medicines to help patients around the world? If the answer is yes, then Editas Medicine is the place for you.

In this role, you will join the Analytical Development group in the Biological Development function, dedicated to assay development for analysis and characterization of gene and cell therapy products. You will be challenged and gain unique experience in analytical development for multiple components of in vivo and ex vivo gene editing therapeutic products including protein, AAV, ribonucleoprotein complex (RNP), and gene edited NK cell products. You will also be responsible for early RNP complexation process development, and early assessment of gene and cell product degradation pathways to define quality attributes. This is a unique opportunity to learn cutting-edge analytical development for gene and cell therapy, and to make an immediate impact in an innovative, fast-paced environment!

Key Responsibilities

Early assay development for structural characterization and functional analysis of protein, RNP, AAV, edited IPSC/iNK cells
Develop early analytical strategy to assess the developability of gene and cell therapy products. Understand the degradation pathways to define preliminary product quality attributes.
Build and strengthen AAV analytical capabilities, including establishing methods for assessment of viral capsid content, composition, and quality (HPLC, AUC, ELISA, etc.)
Interface with CMC to define robust and scalable processes for RNP
Interact closely with research project teams and provide analytical support for critical, late-stage Research experiments
Serve as Research Analytical Development representative on cross-functional teams
Author, review, and approve protocols, technical documents, and reports in support of regulatory submissions

Requirements

Ph.D. in analytical chemistry, biochemistry, biophysics, or related discipline with 1-2 years of relevant industry experience; OR a Bachelors/Masters with 4-6 years of relevant industry experience
Prior industry experience in analytical assay development in AAV and cell therapy is strongly preferred but not required
Experience in one or both of the following areas: viral particle characterization (ddPCR/qPCR, chromatography, AUC, ELISA) or cellular characterization assays (flow cytometry, ELISA, STR DNA profiling, potency and viability assays)
Proven ability to troubleshoot complex problems in viral and/or cellular analytical development
Successful track record of identifying and onboarding new assays/techniques for viral and/or cellular analytical development
Experience in biochemical and analytical methods used to characterize protein and protein-nucleic acid interactions is a plus
Attention to detail and strong organizational skills
Excellent oral and written communication skills

Show Full Description

See how you match
to the job

Upload my resume

Download the
LiveCareer app and find
your dream job anywhere

Similar Jobs

View All

Want to see jobs matched to your resume?
Upload One Now!

Scientist I Research Analytics

Editas Medicine, Inc.

Posted 8 months ago

VIEW JOBS What if you could repair broken genes? That is the question we ask ourselves at Editas Medicine. We're focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for many diseases. We're looking for talented, dedicated, passionate people to join our team and help us pioneer this field and do big, bold things that have never been achieved before. Are you full of hope, possibilities, and a belief that, working together, we can truly revolutionize the development of medicines to help patients around the world? If the answer is yes, then Editas Medicine is the place for you. In this role, you will join the Analytical Development group in the Biological Development function, dedicated to assay development for analysis and characterization of gene and cell therapy products. You will be challenged and gain unique experience in analytical development for multiple components of in vivo and ex vivo gene editing therapeutic products including protein, AAV, ribonucleoprotein complex (RNP), and gene edited NK cell products. You will also be responsible for early RNP complexation process development, and early assessment of gene and cell product degradation pathways to define quality attributes. This is a unique opportunity to learn cutting-edge analytical development for gene and cell therapy, and to make an immediate impact in an innovative, fast-paced environment! Key Responsibilities * Early assay development for structural characterization and functional analysis of protein, RNP, AAV, edited IPSC/iNK cells * Develop early analytical strategy to assess the developability of gene and cell therapy products. Understand the degradation pathways to define preliminary product quality attributes. * Build and strengthen AAV analytical capabilities, including establishing methods for assessment of viral capsid content, composition, and quality (HPLC, AUC, ELISA, etc.) * Interface with CMC to define robust and scalable processes for RNP * Interact closely with research project teams and provide analytical support for critical, late-stage Research experiments * Serve as Research Analytical Development representative on cross-functional teams * Author, review, and approve protocols, technical documents, and reports in support of regulatory submissions * Ph.D. in analytical chemistry, biochemistry, biophysics, or related discipline with 1-2 years of relevant industry experience; OR a Bachelor's/Master's with 4-6 years of relevant industry experience * Prior industry experience in analytical assay development in AAV and cell therapy is strongly preferred but not required * Experience in one or both of the following areas: viral particle characterization (ddPCR/qPCR, chromatography, AUC, ELISA) or cellular characterization assays (flow cytometry, ELISA, STR DNA profiling, potency and viability assays) * Proven ability to troubleshoot complex problems in viral and/or cellular analytical development * Successful track record of identifying and onboarding new assays/techniques for viral and/or cellular analytical development * Experience in biochemical and analytical methods used to characterize protein and protein-nucleic acid interactions is a plus * Attention to detail and strong organizational skills * Excellent oral and written communication skills

Principal Research Scientist I Computational Immunology Rheumatological Lead

Abbvie, Inc

Posted Yesterday

VIEW JOBS About AbbVie AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn. The Genomics Research Center (GRC) is a center of excellence for genetics and genomics that supports both Discovery and Development. The GRC plays an integral role towards our goal of developing world class genetics and genomics research, focusing on finding the right targets and helping us better understand not only human disease biology but also the behavior of and response to our drugs in clinical trials. Within the GRC, the Department of Bioinformatics is responsible for data analysis and provides analytical insight for both internal and external data. This involves the identification and characterization of underlying genetic, epigenetic, or genomic factors that are associated with disease diagnosis, prognosis and response (efficacy and safety) to drug treatment, identification of new targets, and interpretation of the impact of genetic and genomic evidence from population-based studies. We have an exciting opportunity for a Principal Computational Biologist Immunology, based in Cambridge Massachusetts. The candidate will lead the computational effort supporting rheumatological research and development efforts in Immunology therapeutic area at Abbvie. Key Responsibilities: * Act as the rheumatological disease lead within the Systems Computational Biology group for data and computational strategies for rheumatological diseases, including but not limiting to rheumatoid arthritis, lupus, and Sjogren's disease * Collaborate with research & clinical scientists to conceive informatics analysis strategy and independently execute bioinformatics analysis, particularly focusing on functional interpretation and hypothesis generation that support discovery, pre-clinical studies and development projects such as new target identification, patient stratification and biomarker development * Collaborate with bioinformatics scientists and data engineers for complex and integrated bioinformatics analyses leveraging available genetic and multi-omics datasets * Identify relevant internal and external data and knowledge resources and propose integration mechanisms for data integration * Be abreast with most current systems analysis and machine learning methodology and algorithms and introduce them in-house when appropriate. * Communicate analytical analysis verbally and in writing for scientific and technical audiences. * Mentor junior computational scientists Qualifications Qualifications: * PhD in Biological sciences (immunology strongly preferred) with strong quantitative background, involving the analysis of large scale complex data such as next generation sequencing, populational genetics, with typically 6+ years of experience. * Hands on experience in genomics (single cell preferred), immunoprofiling (CyTOF, immune cell repertoire) data analyses using existing and custom pipelines are preferred. * Experience in research project management is required. * Knowledge in functional analysis tools (IPA, GSEA, etc.) and relevant databases (GEO, GTEX, DICE, etc.) and experience in developing custom computational analysis pipeline leveraging these resources is highly preferred * Fluent in scientific scripting languages such as R, Perl/Python. Very comfortable working in both linux and windows environment. Key AbbVie Competencies: * Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance. * Learns fast, grasps the "essence" and can change the course quickly where indicated. * Raises the bar and is never satisfied with the status quo. * Creates a learning environment, open to suggestions and experimentation for improvement. * Embraces the ideas of others, nurtures innovation and manages innovation to reality. Significant Work Activities N/A Travel No Job Type Experienced Schedule Full-time Job Level Code M Equal Employment Opportunity At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.

Research Associate/Senior Research Associate Discovery Analytics

Bluerock Therapeutics

Posted 5 days ago

VIEW JOBS Who is BlueRock?BlueRock Therapeutics, a wholly-owned and independently operated subsidiary of Bayer AG, is a leading engineered cell therapy company using its unique cell+gene platform to direct cellular differentiation and genetically engineer cells to create a new generation of cellular medicines that address large patient populations suffering from neurological, cardiovascular, and immunology diseases.The convergence of cell biology and genetic engineering is creating fundamental new ways to impact disease. Founded in 2016 to capitalize on these technological breakthroughs, we are advancing our novel cell+gene platform to develop, manufacture, and deliver an entirely new generation of authentic and engineered cell therapies across three therapeutic areas: neurology, cardiology, and immunology.What Are We Doing?Our foundational science harnesses the ability to create and then direct the differentiation of universal pluripotent stem cells into authentic, functional cells that can be used as allogeneic cellular therapies to treat a broad array of diseases. We can also further engineer these cells, enabling them to produce enzymes, antibodies, and other proteins for additional therapeutic benefit. We are passionate about delivering on the promise of cellular and gene therapy, shaping the future of cellular medicine, and delivering new therapies to millions of patients with treatment options. We are seeking individuals who are collaborative, thrive in a fun and dynamic culture, and are steadfast in the commitment to advance cutting-edge cellular therapies to impact patients’ lives. Description of Position:BlueRock Therapeutics is seeking a highly motivated individual to join our Genome Sciences team in Cambridge, MA. This individual will join a group of scientists who are developing methods to characterize novel cell therapies derived from induced Pluripotent Stem Cells (iPSC). The successful candidate will have hands on experience in cell culture, DNA sequencing and qPCR. This is an exciting and challenging opportunity to contribute to bringing a new class of cellular therapies to patients with seriously debilitating diseases using our unique cell+gene platformResponsibilities<ul> <li>Perform experiments to characterize the phenotype of cell pools and clonal cell lines in a process development environment. Methods used include qPCR, NGS library preparation and flow cytometry. </li> <li>Collect and analyze assay data and establish ranges for assay controls.</li> <li>Document experimental data in electronic laboratory notebooks in a timely and accurate manner in accordance with the company quality management system.</li> <li>Author and review SOPs, reports and other technical documents.</li> <li>Assist in the evaluation and development of new technologies to characterize cell lines. </li> <li>Present scientific data to colleagues in group meetings, prepare and present internal and external presentations (presentations, posters, publications) as required.</li> <li>Perform additional duties to support the safe and efficient operation of the laboratory, and other duties as assigned.</li> <li>Develop and maintain effective cross-functional working relationships; respond positively and in timely manner to requests for support from across the organization.</li> </ul> Requirements<ul> <li>B.S. in a biological science and a minimum of two years industry experience in a biotechnology industry setting. </li> <li>Experience with creating NGS libraries, especially for scRNA-seq. Experience with cell culture and transfection. Experience with iPSC transfection techniques is a plus.</li> <li>Highly detail oriented and able to keep meticulous records of experiments</li> <li>Practical understanding of qualification of analytical assays (e.g. to GLP or GMP regulations) is a strong plus.</li> <li>Skilled in working with a larger team to address a wide range of complex problems in creative and practical ways. </li> <li>Self-motivated and willing to accept responsibilities outside of initial job description</li> <li>Comfortable in a fast-paced small company environment and able to adjust workload based upon changing priorities.</li> </ul> <ul><li>Experience using qPCR or digital PCR to measure DNA or mRNA levels. </li></ul>

Apply