Scientist I, Research Analytics

Editas Medicine Cambridge , MA 02138

Posted 2 months ago

What if you could repair broken genes? That is the question we ask ourselves at Editas Medicine. Were focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for many diseases.

Were looking for talented, dedicated, passionate people to join our team and help us pioneer this field and do big, bold things that have never been achieved before.

Are you full of hope, possibilities, and a belief that, working together, we can truly revolutionize the development of medicines to help patients around the world? If the answer is yes, then Editas Medicine is the place for you.

In this role, you will join the Analytical Development group in the Biological Development function, dedicated to assay development for analysis and characterization of gene and cell therapy products. You will be challenged and gain unique experience in analytical development for multiple components of in vivo and ex vivo gene editing therapeutic products including protein, AAV, ribonucleoprotein complex (RNP), and gene edited NK cell products. You will also be responsible for early RNP complexation process development, and early assessment of gene and cell product degradation pathways to define quality attributes. This is a unique opportunity to learn cutting-edge analytical development for gene and cell therapy, and to make an immediate impact in an innovative, fast-paced environment!

Key Responsibilities

  • Early assay development for structural characterization and functional analysis of protein, RNP, AAV, edited IPSC/iNK cells
  • Develop early analytical strategy to assess the developability of gene and cell therapy products. Understand the degradation pathways to define preliminary product quality attributes.
  • Build and strengthen AAV analytical capabilities, including establishing methods for assessment of viral capsid content, composition, and quality (HPLC, AUC, ELISA, etc.)
  • Interface with CMC to define robust and scalable processes for RNP
  • Interact closely with research project teams and provide analytical support for critical, late-stage Research experiments
  • Serve as Research Analytical Development representative on cross-functional teams
  • Author, review, and approve protocols, technical documents, and reports in support of regulatory submissions

Requirements

  • Ph.D. in analytical chemistry, biochemistry, biophysics, or related discipline with 1-2 years of relevant industry experience; OR a Bachelors/Masters with 4-6 years of relevant industry experience
  • Prior industry experience in analytical assay development in AAV and cell therapy is strongly preferred but not required
  • Experience in one or both of the following areas: viral particle characterization (ddPCR/qPCR, chromatography, AUC, ELISA) or cellular characterization assays (flow cytometry, ELISA, STR DNA profiling, potency and viability assays)
  • Proven ability to troubleshoot complex problems in viral and/or cellular analytical development
  • Successful track record of identifying and onboarding new assays/techniques for viral and/or cellular analytical development
  • Experience in biochemical and analytical methods used to characterize protein and protein-nucleic acid interactions is a plus
  • Attention to detail and strong organizational skills
  • Excellent oral and written communication skills
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VIEW JOBS 6/11/2020 12:00:00 AM 2020-09-09T00:00 What if you could repair broken genes? That is the question we ask ourselves at Editas Medicine. We're focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for many diseases. We're looking for talented, dedicated, passionate people to join our team and help us pioneer this field and do big, bold things that have never been achieved before. Are you full of hope, possibilities, and a belief that, working together, we can truly revolutionize the development of medicines to help patients around the world? If the answer is yes, then Editas Medicine is the place for you. In this role, you will join the Analytical Development group in the Biological Development function, dedicated to assay development for analysis and characterization of gene and cell therapy products. You will be challenged and gain unique experience in analytical development for multiple components of in vivo and ex vivo gene editing therapeutic products including protein, AAV, ribonucleoprotein complex (RNP), and gene edited NK cell products. You will also be responsible for early RNP complexation process development, and early assessment of gene and cell product degradation pathways to define quality attributes. This is a unique opportunity to learn cutting-edge analytical development for gene and cell therapy, and to make an immediate impact in an innovative, fast-paced environment! Key Responsibilities * Early assay development for structural characterization and functional analysis of protein, RNP, AAV, edited IPSC/iNK cells * Develop early analytical strategy to assess the developability of gene and cell therapy products. Understand the degradation pathways to define preliminary product quality attributes. * Build and strengthen AAV analytical capabilities, including establishing methods for assessment of viral capsid content, composition, and quality (HPLC, AUC, ELISA, etc.) * Interface with CMC to define robust and scalable processes for RNP * Interact closely with research project teams and provide analytical support for critical, late-stage Research experiments * Serve as Research Analytical Development representative on cross-functional teams * Author, review, and approve protocols, technical documents, and reports in support of regulatory submissions * Ph.D. in analytical chemistry, biochemistry, biophysics, or related discipline with 1-2 years of relevant industry experience; OR a Bachelor's/Master's with 4-6 years of relevant industry experience * Prior industry experience in analytical assay development in AAV and cell therapy is strongly preferred but not required * Experience in one or both of the following areas: viral particle characterization (ddPCR/qPCR, chromatography, AUC, ELISA) or cellular characterization assays (flow cytometry, ELISA, STR DNA profiling, potency and viability assays) * Proven ability to troubleshoot complex problems in viral and/or cellular analytical development * Successful track record of identifying and onboarding new assays/techniques for viral and/or cellular analytical development * Experience in biochemical and analytical methods used to characterize protein and protein-nucleic acid interactions is a plus * Attention to detail and strong organizational skills * Excellent oral and written communication skills Editas Medicine, Inc. Cambridge MA

Scientist I, Research Analytics

Editas Medicine