Scientist I, Molecular Biology AND Expression, Protein Sciences

About Soleil Labs: Based in South San Francisco, Soleil Labs is a biotechnology company devoted to the discovery of originator biopharmaceutical medicines across a range of therapeutic areas.  Uniquely integrated with the dedicated TCG Labs venture fund, we are building Soleil Labs with a single goal in mind:  the time- and resource-efficient translation of compelling scientific insights into promising therapies.  This distinctive environment offers drug hunters an unparalleled opportunity to become essential members of a collaborative and fast-paced team enduringly positioned for the discovery of exciting new therapeutic candidates.

About the Position: 

TCG Labs-Soleil is seeking an experienced and motivated scientist with a passion for developing therapeutics to join our Protein Sciences team and implement efficient cloning and expression capabilities in support of a highly productive therapeutic biologics Research team. The successful candidate will have extensive skills in molecular biology and experience in expression and purification of recombinant proteins using both transient and stable systems.   As part of an interdisciplinary research team, the selected individual will be a key contributor to the progression of an exciting and diverse therapeutic pipeline.

Responsibilities:

• Perform molecular biology techniques including high throughput PCR and molecular cloning, and from small to large scale plasmid DNA purification.
• Design and generate recombinant antigen protein expression plasmid for bacterial and mammalian expression systems.
• HTP transient expression of antibodies in mammalian cell lines on automated platform.
• Develop and generate antibody stable expression in CHO and 293.
• Accurately and consistently record experimental methods, materials, and results.
• Provide regular progress updates and present data at internal team meetings and departmental meetings.

Qualifications:

• M.S. in Molecular Biology, Chemical Biology, Biochemistry or other relevant discipline with 5+ years of relevant experience, or B.S. with equivalent experience.
• Self-motivated and passionate about automation and new technology.
• Extensive hands-on experience with prime design and PCR.
• Experienced with various molecular cloning methods such as seamless and GoldenGate cloning is required.
• Extensive hands-on experience with transient mammalian expression (HEK293 and CHO) is required.
• Hands-on experience with automation using liquid handler is highly desired.
• Experience with recombinant protein expression in bacterial and/or other expression system is highly desired, especially good understanding on solubility enhancing techniques.
• Hands-on experience with stable mammalian expression (HEK293 and CHO) is desired.
• Hands-on experience of mono- and bi-specific antibodies, Fab fragments, scFv, VHH, and various antibody-fusion formats is desired.
• Strong organizational skills and ability to handle multiple projects simultaneously.
• Comfortable to work in a fast-paced work environment.

EEO Statement

Soleil Labs, LLC is an Equal Opportunity Employer. We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy (including childbirth and related conditions), national origin, ancestry, age, marital status, military or veteran status, sexual orientation, genetic information, physical or mental disability or medical condition as defined by applicable equal opportunity laws. Any request for accommodation can be directed to careers@soleil.bio. 

Benefits and Compensation 

TCG Labs-Soleil provides a competitive benefits package that includes access to Medical, Dental, and Vision Insurance, Life Insurance, Short and Long Term Disability, Health Savings Account (HSA), Flexible Spending Accounts (FSA), 401k plan and PTO.

The anticipated salary range for fully qualified candidates applying for this role will be $98,000 - $171,875 annually (not including discretionary bonus, equity, and benefits). The final salary offered will be dependent on several factors that include but are not limited to relevant previous experience including duration and type of experience within the industry, education, and internal equity.

Staffing Agencies

TCG Labs-Soleil does not accept unsolicited agency resumes and will not pay fees to any third-party agency or firm that doesn’t have a signed agreement with TCG Labs-Soleil. Please do not send agency CVs/resumes through TCG Labs-Soleil website or TCG Labs-Soleil Employees.  Inquiries must be sent to contact@tcglsoleil.com with the Subject Heading:  Staffing Agency Request.