Scientist I, Dmpk

The Position:

The Drug Metabolism and Pharmacokinetics (DMPK) team at Maze Therapeutics is seeking a qualified and highly motivated Scientist I to join us in advancing our therapeutic programs. In this lab-based role, you'll apply your expertise in LC-MS/MS (QQQ) and/or LC-HRMS (Orbitrap) to measure concentrations of small molecules, analyze PK data, and generate reports that support our drug discovery efforts. You will work closely with the lead Scientist in the PK group and collaborate across multiple projects to ensure high-quality, timely data delivery. This role is ideal for someone who values precision, embraces challenges, and excels in a hands-on laboratory environment.

Your Impact:

• Prepare and process samples (plasma, blood, and tissues) for PK and/or biomarker analyses.
• Collaborate with colleagues to coordinate acquisition of test articles, study schedules, and sample management.
• Measure analyte concentrations using LC-MS, including developing and troubleshooting methods.
• Process bioanalytical data to calculate PK parameters and generate detailed PK reports.
• Partner with scientists to upload PK data into our electronic database.
• Review and QC PK data and reports from CROs or internal teams.
• Support regulatory submissions.
• Maintain thorough, organized records in electronic laboratory notebook.

Skills and Qualifications:

• A degree in chemistry or biological sciences (bachelor's with 6+ years, master's with 3+ years, and PhD with industry experience)
• Hands-on experience maintaining and troubleshooting analytical equipment.
• Proficiency in processing and analyzing LC-MS data independently
• Strong skills in Excel, GraphPad Prism, and scientific writing.
• A detail-oriented approach with excellent laboratory practices and the ability to write and review PK reports
• A team-oriented mindset and strong communication skills
• Additional desired, but not required skills:
• Proficiency with Certara Phoenix WinNonLin
• Experience working in regulated laboratory environments
• Familiarity with Mosaic.

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company's pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together- Our path is paved with challenges, but with resilience and a team-first mentality, we'll achieve our mission.

Impact Obsessed- We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True- Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $131,000 - $160,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.