Scientist I, Discovery And Early Development Biomarkers

Biogen Idec Cambridge , MA 02138

Posted 4 months ago

Job Description:

The successful candidate will be capable of multitasking, setting goals, priorities, and planning timelines. In addition, highly effective communication and collaboration are crucial.


  • Assist in developing scientific approaches to identify novel diagnostic, prognostic, and pharmacodynamic biomarkers to enable go/no go decisions for drug development programs

  • Perform biochemical assays indicative of target engagement, efficacy, PK/PD relationships, and novel biomarkers to characterize molecules for potential therapeutic effects

  • Participate in research teams to support biomarker discovery and development

  • Prepare, review and deliver high quality scientific presentations for internal/external use

  • Develop strategies to identify and validate novel biomarkers to assist in program progression

  • Learn new techniques and approaches as needed to tackle relevant questions


Working knowledge and experience of current approaches and instrumentation involved in protein biochemistry and molecular biology techniques (e.g. immunoassays, western blotting, protein-protein interactions, protein purification, immunoprecipitation, real-time PCR, enzymatic assays) is required

  • Ability to analyze and interpret biomarker data from preclinical and clinical trials to establish target engagement/pharmacodynamic effect criteria

  • Track record in neuroscience, including knowledge of neurodegenerative diseases (AD, PD, ALS). Experience working in Parkinson's Disease is preferred

  • Expertise in the cutting edge assay technologies and excellent assay troubleshooting skills

  • Ability to work independently or with minimal supervision in managing projects and priorities

  • Experience in translating biomarker assays from preclinical models to the clinical setting is preferred


PhD with postdoctoral experience or BS/MS with 7+ years of academic/industry experience

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Scientist I, Discovery And Early Development Biomarkers

Biogen Idec