Scientist, Discovery Pharmacology

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

Responsibilities:

• Provides strategic and technical leadership to large molecule therapeutic discovery projects.

• Utilizes SPR / Biacore / Octet and other methods to accurately characterize antibody-target and other protein-protein interaction affinities

• Develops and performs additional assays to identify and investigate novel large-molecule therapeutics.

• Independently run studies to precisely characterize and quantify antibody-target and other protein-protein interactions and affinities using SPR (Biacore), Octet, ELISA-based, and other relevant assays

• Supports efforts to gain structural and mechanistic insights on novel large molecule therapeutics by independently developing and running novel assays to investigate large molecule interactions, affinities, activities, stability, effects on cellular pathways and biomarkers, etc.

• Works collaboratively across a wide range of therapeutic discovery, characterization, selection, and optimization programs to support drug discovery efforts

• Provides detailed reports that can be used by teams for candidate selection and regulatory filings

Requirements:

• BS with 5+ years, MS with 3+ years or PhD with 0 years of experience in Biophysics, Biochemistry, or a related field

• Experience leading antibody:target and protein:protein binding and mechanistic studies is required (e.g. SPR (Biacore), Octet, ELISA).

• Experience developing, optimizing, and running protein-protein and cell-based binding and activity assays is desired

• Experience generating data / documents suitable for regulatory filings desired

• Demonstrated ability to work effectively and collaboratively with other scientists on cross-functional projects teams

• Experience working with multiple protein targets, both hands-on and coordinating with CROs and/or academic partners

• Excellent oral and written communication skills

• Motivated, scientifically driven individual with a creative approach to complex biochemical problem solving

Salary Range: 123,000.00 to 158,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers

This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

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