Scientist - Discovery Neuroinflammation Group

Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

What You Will Achieve

The Discovery Neuroinflammation Group in the Inflammation and Immunology Research Unit (I&I) is looking for a motivated, innovative and enthusiastic researcher to join our group in studying inflammatory pathways in neurodegenerative diseases with a focus on myeloid cell biology and cellular uptake/degradation pathways. This Scientist will work in a matrix structure within the department supporting both in vitro and in/ex vivo studies that investigate mechanisms for neuroinflammation and novel targets and assets for the Discovery Neuroinflammation Group. The ideal candidate will have a diverse biology and immunology background and have a history of success in developing assays, implementing new technologies and triaging problems in biological systems. The candidate will be a key contributor in delivering data and recommendations for decisions of proposed and active programs.

How You Will Achieve It

• Plan and execute laboratory experiments to produce robust, decision-making data for the Discovery Neuroinflammation Group.

• Develop relevant in vitro assays to evaluate disease phenotypes in neuroinflammation.

• Investigate novel pathways involved in neurodegenerative diseases with a focus on lipid and immune cell influences.

• Lead evaluations of new targets in neuroinflammation for portfolio entry.

• Support in vitro, in/ex vivo studies as needed within Neuroinflammation Group with assay execution & analysis using multiparametric assays including flow cytometry, histology, high content imaging, and biochemical assays.

• Run high-parameter tissue imaging to validate target expression and determine cell components and localization.

• Collaborate with other Discovery and Preclinical groups in I&I as well as key individuals in relevant partner lines.

• Prepare and present experimental results to project teams.

• Publish and present at external meetings.

• Maintain high quality experimental records within electronic laboratory notebook.

Qualifications

Must-Have

• BA/BS (5 years of experience), MS (2-4 years of experience) or, PhD (0-1 year of experience) in biology, immunology, or neuroscience with laboratory experience relevant to this position.

• Must be scientifically self-motivated and capable of independently conceiving, conducting, and critically analyzing their own innovative research with minimal supervision.

• Experience with human and murine neuronal cell culture and assay development

• Expertise in Lipid loading and related pathway analysis

• Expertise in core molecular biology skills (PCR, ELISA, WB/IP, Plate-based Assays, DNA/RNA Isolation)

• Ability to conduct data analysis using Microsoft Excel, GraphPad Prism, FlowJo, or equivalent software.

• Ability to complete experiments and present results in individual and group settings.

• Ability to learn novel skills and flourish in a highly-matrixed organization as well as work well within multidisciplinary teams.

• Ability to make recommendations to effectively resolve issues by using sound judgment that is consistent with standards, practices, policies, procedures, and regulations.

• Proven verbal and written communication skills, and the ability to work in a collaborative team environment.

Nice-to-Have

• Experience with in vitro gene editing approaches.

• Experience with iPSC culture a plus.

• Experience with high-parameter flow cytometry, immunohistochemistry & immunofluorescence.

Other Job Details:

• Last Date to Apply for Job: June 28th, 2024

• Work Location Assignment: Flexible

Flexible colleagues are assigned a Pfizer site within a commutable distance where they work about 2-3 days weekly to connect and innovate with their team face-to-face. However, they also benefit from being able to work offsite regularly when it makes business sense to do so.

The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development