Scientist, Car-T Applications

Bio-Techne Minneapolis , MN 55415

Posted 4 weeks ago

Job Details

Level: Experienced

Job Location: Minneapolis - Minneapolis, MN

Position Type: Full Time

Education Level: Graduate Degree

Salary Range: Undisclosed

Travel Percentage: Negligible

Job Shift: Day

Description

By joining the Bio-Techne team you will have an impact on future cutting-edge research. Bio-Techne, and all of its brands, provides tools for researchers in Life Sciences and Clinical Diagnostics.

Bio-Techne is seeking a Scientist to perform process development work in their Cell and Gene Therapy (CGT) division. This position is primarily responsible for the continued development of TcBuster, our transposon technology for non-viral gene editing cell therapy manufacturing. The role will be a multi-disciplinary working on primary cell gene editing, cell activation/expansion methodologies, and functional testing. The position may also work closely with customers in drafting SOW specifications, and project plans for using TcBuster to manufacture their cell therapy.

The ideal candidate will have prior process development experience in the manufacture of T cell therapies. A strong background in working with a wide variety of clinically relevant manufacturing instrumentation is highly desired.

Key Responsibilities:

  • Design and perform complex experiments independently

  • Analyze data, draw conclusions, and generate summary reports that can be used to support IND filings

  • Develop and write work instructions, SOPs, and master batch records

  • Expected to help train and mentor other personnel as needed

  • Advance Bio-techne products and content through process development

  • Effectively communicate results to customers as needed

  • Work across multiple CGT groups and product development programs to integrate other products used in this space

Qualifications

Education and Experience:

  • PhD in immunology, molecular biology, biomedical engineering, or related degree with 2-5 years of experience

  • Primary cell culture experience a requirement, preferably with T cells and NK cells

  • Previous experience working with adoptive T-cell therapies (CAR-T and TCR) preferred

  • Experience with analytical methods such as flow cytometry, qPCR, and ddPCR

  • Ability to work independently, stay organized, and handle multiple projects at the same time while executing within a timeline

  • Knowledge of gene editing methodologies included electroporation and use of non-viral editing modalities preferred

  • Previous work in a GMP manufacturing environment is desired

  • Outstanding written and oral communication.

Education and Experience:

  • PhD in immunology, molecular biology, biomedical engineering, or related degree with 2-5 years of experience

  • Primary cell culture experience a requirement, preferably with T cells and NK cells

  • Previous experience working with adoptive T-cell therapies (CAR-T and TCR) preferred

  • Experience with analytical methods such as flow cytometry, qPCR, and ddPCR

  • Ability to work independently, stay organized, and handle multiple projects at the same time while executing within a timeline

  • Knowledge of gene editing methodologies included electroporation and use of non-viral editing modalities preferred

  • Previous work in a GMP manufacturing environment is desired

  • Outstanding written and oral communication.

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Scientist, Car-T Applications

Bio-Techne