Scientist, Biotransformation, Drug Metabolism And Pharmacokinetics

Genentech South San Francisco , CA 94080

Posted 1 month ago

We are seeking a highly motivated Scientist to join the Biotransformation Group in the Department of Drug Metabolism and Pharmacokinetics at Genentech (South San Francisco, CA). The successful candidate will support discovery biotransformation related studies of small molecule, peptide and other modalities in the discovery stage.

Primary responsibilities:

  • Profiling and identifying/elucidating drug metabolites in in vitro and in vivo biological matrices (e.g., hepatocytes, blood) using high resolution LC-MS/MS and metabolite identification software

  • Developing and implementing appropriate assays (e.g., Met ID, reactivity) and strategies to support design and optimization of small molecules (non-covalent and covalent binders) and other modalities (e.g., peptides, degraders, oligonucleotides)

  • Identifying soft spots, major metabolic pathways, responsible metabolizing enzymes and structure-metabolism relationships

  • Working with medicinal chemists to influence drug design with biotransformation insights

  • Working with CROs on assay development and data QC

  • Evaluating new technologies and software

Key qualifications:

  • PhD degree in chemistry, biochemistry, pharmaceutical sciences or other related disciplines.

  • Good understanding of metabolic enzyme reaction mechanisms, enzyme kinetics and clearance mechanism in support of drug discovery programs

  • Experience with MS-based structural elucidation of unknown small molecule and peptide structures, high resolution LC-MS/MS instrumentation and data analysis, method development and trouble-shooting

  • Proven abilities in determining the biotransformation pathways of small molecules, peptides and/or other modalities

  • Proven track record of scientific achievements and communication skills

#LI-ES1 #scientistjob #dmpk

icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon
lc_ad

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Senior Scientist Drug Metabolism And Pharmacokinetics

Global Blood Therapeutics, Inc.

Posted 2 weeks ago

VIEW JOBS 10/7/2020 12:00:00 AM 2021-01-05T00:00 SENIOR SCIENTIST - DRUG METABOLISM AND PHARMACOKINETICS Position Summary: As a senior scientist, a successful candidate will serve as DMPK project representative on cross-functional discovery and development project teams to drive target product profile milestone transitions from lead identification to regulatory submissions. The position will be responsible to characterize the absorption, distribution, metabolism, excretion and PK-PD-efficacy (exposure-effect) relationship of drug candidates spanning from early discovery to clinical stage development. Essential Duties and Responsibilities: * Serve as a DMPK project representative, design and execute DMPK strategies to support product advancement * Draft study protocols and coordinate execution of DMPK studies with multiple functional areas and CROs, work closely with project teams, line management and CROs to ensure high quality and timely delivery of results and reports * Perform DMPK data analysis and generate study reports for detailed pharmacokinetics characteristics assessment and human dose projection * Participate in the development and implementation of new technologies within the field of DMPK, keep abreast of relevant literature and develop visibility outside of functional area * Assume responsibility for direct reports as needed, including recruiting, managing, mentoring and developing scientific staff Qualifications: * A Ph.D. degree with at least 2 years or a M.S. degree with at least 5 years of relevant DMPK experiences in Pharma/Biotech industry * Excellent communication and organizational skills, accountable, results and detailed-oriented, and thrive on working in a team-based environment are essential * In-depth understanding of ADME-PK principles and the application of ADME-PK information supporting early discovery, lead optimization and development of candidate selection Fit with GBT culture: * Ability to build strong relationships with co-workers of various backgrounds and expertise * Ability to function at a high level in a team setting whether leading the group or acting as an individual contributor * Values-based leadership consistent with GBT's Core Values * Excitement about the vision and mission of GBT * Flexibility * Integrity NOTE: This position summary is not intended to be all-inclusive. Employee may perform other related duties as negotiated to meet the ongoing needs of the organization. Global Blood Therapeutics is an equal opportunity employer, and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or any other characteristic protected by law. Global Blood Therapeutics, Inc. South San Francisco CA

Scientist, Biotransformation, Drug Metabolism And Pharmacokinetics

Genentech