We are seeking a highly motivated Scientist to join the Biotransformation Group in the Department of Drug Metabolism and Pharmacokinetics at Genentech (South San Francisco, CA). The successful candidate will support discovery biotransformation related studies of small molecule, peptide and other modalities in the discovery stage.
Profiling and identifying/elucidating drug metabolites in in vitro and in vivo biological matrices (e.g., hepatocytes, blood) using high resolution LC-MS/MS and metabolite identification software
Developing and implementing appropriate assays (e.g., Met ID, reactivity) and strategies to support design and optimization of small molecules (non-covalent and covalent binders) and other modalities (e.g., peptides, degraders, oligonucleotides)
Identifying soft spots, major metabolic pathways, responsible metabolizing enzymes and structure-metabolism relationships
Working with medicinal chemists to influence drug design with biotransformation insights
Working with CROs on assay development and data QC
Evaluating new technologies and software
PhD degree in chemistry, biochemistry, pharmaceutical sciences or other related disciplines.
Good understanding of metabolic enzyme reaction mechanisms, enzyme kinetics and clearance mechanism in support of drug discovery programs
Experience with MS-based structural elucidation of unknown small molecule and peptide structures, high resolution LC-MS/MS instrumentation and data analysis, method development and trouble-shooting
Proven abilities in determining the biotransformation pathways of small molecules, peptides and/or other modalities
Proven track record of scientific achievements and communication skills
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