Scientist, Biochemistry/Enzymology

Agios Pharmaceuticals Cambridge , MA 02138

Posted 3 weeks ago

Scientist, Biochemistry/Enzymology

Agios (agios.com) is a biopharmaceutical company committed to applying our scientific leadership in cellular metabolism to transform the lives of patients with cancer and rare genetic diseases. We are delivering a robust research and discovery pipeline across both therapeutic areas. Agios has two approved oncology precision medicines and multiple first-in-class investigational therapies in clinical and/or preclinical development.

We're seeking a highly skilled Scientist with motivation and leadership skills to join a world-class biochemistry team at Agios Pharmaceuticals. The successful candidate will provide expertise in enzymology as applied to drug discovery in partnership with multi-disciplinary drug-hunting teams. Responsibilities will include multiple aspects of biochemistry to impact discovery of novel medicines in Oncology and Rare Genetic Disorders of Metabolism.

Job Responsibilities

  • Conceptual design, execution, and documentation of biochemical assays to characterize enzyme targets

  • Responsible for generating high quality data in protein chemistry & engineering, protein analytics, enzyme kinetics and/or biophysical methods to interrogate detailed molecular interactions

  • Devise innovative assay development for evaluation of new drug candidates library screening against novel targets, including many unstable mutated enzymes

  • Partner with and influence multi-functional teams to guide small molecule drug discovery through the execution of mechanism of action studies

  • Dual leadership from bench and in CRO management; manage external FTE resources; transfer and validate assays to external partners

  • Clear presentation of research outcomes and recommendations to multi-functional teams

Required Qualifications

  • PhD in Enzymology, Biochemistry or related field with 0-5+ years industry research experience or an MS or BS degree with 7-10 years of industry research experience in the context of small-molecule drug discovery

  • Demonstrated ability to solve difficult problems in assay development and mechanistic enzymology

  • Excellent communication, planning, and organizational skills to manage external CRO partners and influence internal matrix collaborations are essential

Preferred Qualifications

  • Relevant drug discovery experience working in a collaborative, matrixed environment

  • Breadth of experience related to biophysical assay development (ITC, DSF, SPR, FRET, or other) for probing protein-ligand interactions

  • Familiarity with database query, curve fitting, and/or scripting software

  • Maintaining involvement with academic research societies within their expert domain

  • Demonstrated flexibility to thrive in a team-oriented, fast paced, technically challenging drug-hunting culture

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Scientist, Biochemistry/Enzymology

Agios Pharmaceuticals