Agios (agios.com) is a biopharmaceutical company committed to applying our scientific leadership in cellular metabolism to transform the lives of patients with cancer and rare genetic diseases. We are delivering a robust research and discovery pipeline across both therapeutic areas. Agios has two approved oncology precision medicines and multiple first-in-class investigational therapies in clinical and/or preclinical development.
We're seeking a highly skilled Scientist with motivation and leadership skills to join a world-class biochemistry team at Agios Pharmaceuticals. The successful candidate will provide expertise in enzymology as applied to drug discovery in partnership with multi-disciplinary drug-hunting teams. Responsibilities will include multiple aspects of biochemistry to impact discovery of novel medicines in Oncology and Rare Genetic Disorders of Metabolism.
Conceptual design, execution, and documentation of biochemical assays to characterize enzyme targets
Responsible for generating high quality data in protein chemistry & engineering, protein analytics, enzyme kinetics and/or biophysical methods to interrogate detailed molecular interactions
Devise innovative assay development for evaluation of new drug candidates library screening against novel targets, including many unstable mutated enzymes
Partner with and influence multi-functional teams to guide small molecule drug discovery through the execution of mechanism of action studies
Dual leadership from bench and in CRO management; manage external FTE resources; transfer and validate assays to external partners
Clear presentation of research outcomes and recommendations to multi-functional teams
PhD in Enzymology, Biochemistry or related field with 0-5+ years industry research experience or an MS or BS degree with 7-10 years of industry research experience in the context of small-molecule drug discovery
Demonstrated ability to solve difficult problems in assay development and mechanistic enzymology
Excellent communication, planning, and organizational skills to manage external CRO partners and influence internal matrix collaborations are essential
Relevant drug discovery experience working in a collaborative, matrixed environment
Breadth of experience related to biophysical assay development (ITC, DSF, SPR, FRET, or other) for probing protein-ligand interactions
Familiarity with database query, curve fitting, and/or scripting software
Maintaining involvement with academic research societies within their expert domain
Demonstrated flexibility to thrive in a team-oriented, fast paced, technically challenging drug-hunting culture