This analytical chemist will help the medicinal chemistry team in analytical related functions, such as routine instrument maintenance (HPLC, Mass Spectrometer, CombiFlash, SFC etc.), troubleshooting, as well as scheduling PM. The incumbent will also develop prep-HPLC methods for medicinal chemists to purify compounds and metabolites.
Primary Duties and Responsibilities:
Perform routine instrument maintenance (HPLC, Mass Spectrometer, CombiFlash, SFC etc.), troubleshooting, as well as scheduling PM.
Perform routine HPLC tests for helping medicinal chemists to check the purity/impurity and prepare CoTs of lead compounds and metabolites for outside tests.
Develop analytical HPLC method with reversed column and different type of chiral columns and transfer the methods to prep-HPLC to help chemists in preparing high purity compounds.
Help chemists to isolate and purify lead compound, metabolite and impurity for structure elucidation and other evaluations.
Develop procedure to assess lead compound solubility under various conditions, such as in water, buffer or biological medias.
Perform stability test under normal and forced conditions for early evaluation of lead compound stability.
Coordinate various outside test services (such as residual solvent test, heavy metal test, elemental screen test (E-scan), etc.
Other Duties and Responsibilities:
Review CRO company's analytical documents such as analytical method, CoA etc.
Communicate with analytical chemists in CMC group.
Strong background in analytical chemistry.
Strong hands on experience in operating different HPLC systems such as Agilent, Gilson, Varian as well as Shimadzu.
Good experience in HPLC method development for lead compound release test.
Strong interpersonal skills.
Ability to work in a fast-paced environment and manage multiple projects.
Very familiar with other instrumentation, such as IR, MS, Karl Fischer, SFC.
Experienced in performing solubility and stability analyses.
Education, prior work experience, and specialized skills and knowledge:
Enanta Pharmaceuticals, Inc.