4D Molecular Therapeutics Inc. Emeryville , CA 94608
Posted 4 weeks ago
GENERAL SUMMARY:
As a Scientist in Vector Innovation you will contribute to improvements to our Therapeutic Vector Evolution platform primarily in novel AAV library design, production, and screening in support of the discovery of novel therapeutic AAV vectors. You will work closely with the entire Vector Innovation & Human Cell and Disease Modelling team onsite to ensure our platform continues to yield best in class novel AAV capsids.
RESPONSIBILITIES:
Lab Activities: 75% of TIME
Design and generate new AAV capsid libraries using various diversification techniques
Contribute to the improvement and execution of AAV capsid library screening and selection platform including NHP tissue processing, episomal recovery and sequencing
Independently and effectively design and execute experiments to test new libraries and detection techniques
Draft study designs, protocols, and maintain an electronic lab notebook
Design and execute experiments to meet strict timelines
Additional responsibilities defined by management
Cross Functional Meetings/Communication: 25% of TIME
Contribute scientific ideas and knowledge in departmental and cross-functional team meetings
Effectively present findings at departmental and cross-functional team meetings
Engage in Vector Innovation study designs for various projects
Present annually at Non-Clinical R&D meeting
Help compile data and author reports for internal and external communication
Communicate effectively with management and their team to achieve departmental and personal goals
QUALIFICATIONS:
Education:
Experience:
5+ years of experience within Biotech or similar industry or relevant academic experience
5+ years of experience in Molecular Biology and cell culturing
Experience in the AAV gene therapy field is preferred
Technical Skills:
Strong in molecular biology techniques, virus handling and transduction
Solid background in library design, production, and high-throughput screening, with a preference for experience in RNA and DNA-based AAV library design and screening
Knowledge about AAV biology, particularly AAV capsid binding, cell integration and localization to the nucleus
Basic cell culture: adherent, suspension, transfection
Protein identification through Western blotting, flow cytometry and immunocytochemistry
Microscopy and use of imaging software
NGS sequence analysis and bioinformatics experience is ideal but not necessary
Non-technical Skills
Demonstrated ability to clearly convey complex scientific information to diverse audiences, both verbally and written
Proven capability to work harmoniously within multidisciplinary teams, sharing knowledge and contributing to a positive team dynamic.
Flexibility in responding to changes in priorities or projects and the ability to thrive in a fast-paced research environment.
Creative and critical thinking skills to identify solutions to scientific challenges, with a willingness to explore various approaches.
Strong time-management and prioritization skills, enabling efficient progress on multiple tasks or projects simultaneously.
A commitment to precision in experimental design, data analysis, and documentation, ensuring the integrity and reliability of research findings.
The resilience to persist through setbacks and challenges, maintaining focus on achieving long-term research goals.
An eagerness to learn and stay informed about the latest developments and technologies in the field of AAV gene therapy.
A strong sense of ethical responsibility and adherence to regulatory standards and safety protocols in research.
Excellent ability to foster and maintain professional relationships, characterized by empathy, respect, and effective communication.
Base salary compensation range:
Bay Area Range: $130,000/yr - $154,000/yr
Please note that compensation varies on a variety of factors including experience, location, etc.
4D Molecular Therapeutics Inc.