Scientist 2, Oligonucleotide Chemist (Synthesis & Purification)

Who We Are: BioMarin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health.

Since our founding in 1997, we have applied our scientific expertise in understanding the underlying causes of genetic conditions to create transformative medicines, using a number of treatment modalities. Using our unparalleled expertise in genetics and molecular biology, we develop medicines for patients with significant unmet medical need. We enlist the best of the best – people with the right technical expertise and a relentless drive to solve real problems – and create an environment that empowers our teams to pursue bold, innovative science.

With this distinctive approach to drug discovery, we’ve produced a diverse pipeline of commercial, clinical and preclinical candidates that have well-understood biology and provide an opportunity to be first-to-market or offer a substantial benefit over existing therapeutic options. Our Culture: From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors.

Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases. Overview: BioMarin is seeking a dedicated and skilled Scientist specializing in oligonucleotide synthesis to contribute to our cutting-edge research and development efforts in nucleic acid-based therapeutics. This role offers a unique opportunity to be part of a dynamic team at the forefront of biotechnology innovation, working on projects that have the potential to transform patient outcomes.

Key Responsibilities: Engage actively in project team discussions across the organization, providing subject matter expertise to support the progression of research projects and the development of new methodologies. Work synergistically with multidisciplinary teams, including bioconjugation specialists, chemists, and biologists, to drive project success and foster a collaborative research environment.

Execute oligonucleotide synthesis utilizing automated solid-phase synthesis methodologies to ensure high-quality and reproducibility of synthesized oligonucleotides. Conduct purification of synthesized oligonucleotides via high-performance liquid chromatography (HPLC) and other relevant techniques to achieve the desired purity and quality standards. Maintain comprehensive and meticulous records of experimental protocols, results, and data analyses, ensuring data integrity and compliance with regulatory standards.

Contribute to the maintenance of a safe and compliant working environment, adhering to all health and safety regulations and promoting a culture of safety within the laboratory. Education & Requirements: PhD degree in Chemistry with 2-4 years of industry experience or Master’s degree with 8-10 years in the biotech or pharmaceutical industry.

Skills: Demonstrated ability to work independently as well as part of a collaborative team environment, with a proactive approach to problem-solving and advancing research programs. Strong enthusiasm for scientific research and innovation, coupled with excellent organizational skills and the ability to manage multiple tasks and projects simultaneously Commitment to maintaining up-to-date knowledge of advancements in oligonucleotide chemistry and related fields, with a willingness to engage in ongoing professional development. Expertise in solid-phase oligonucleotide synthesis and purification, with a strong track record of successful project outcomes.

Excellent written and verbal communication skills, with the ability to effectively present data and findings to both technical and non-technical audiences. Work Style: This is an onsite daily role in San Rafael, CA.

This role will have a daily presence in our Research labs executing experiments. This position represents an exciting opportunity to contribute to BioMarin's mission of developing innovative therapies for patients with serious and life-threatening conditions. We look forward to welcoming a passionate and skilled oligonucleotide chemist to our team.

Note: This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned. An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.