University Of Minnesota Minneapolis , MN 55415
Posted 3 weeks ago
About the Job
This is an entry-level position for a laboratory researcher to join the Liang Lab at the University of Minnesota Twin Cities, Department of Medicine. Our laboratory is dedicated to applying the CRISPR-mediated genome-editing techniques for Gene Therapy and Cancer Research. Our long-term goal is to harness the capabilities of CRISPR to develop precise and targeted genome-editing strategies tailored to the challenges of lung and liver disease. This innovative approach holds promise for unlocking new avenues in gene therapy, cancer research, and immunotherapy.
The researcher will perform research projects that focus on three main areas: (i) developing and enhancing targeting efficiencies of CRISPR, (ii) high-throughput functional analysis of cancer-related genetic mutations, and (iii) identify neoantigens related to lung cancer and liver cancer.
We employ multidisciplinary approaches, including genetic engineered mouse models, CRISPR screens, Prime editors, Protein engineering, AAVs, LNP, single-cell RNA sequencing, FACS, Immunohistochemistry, and Next generation sequence. Additional information on our research projects can be found in our recent publications, including Nature Methods, Nature Biotechnology, Nature Communications, Cancer Research, EMBO molecular medicine, & Oncogene. More information on this research can be found here.
Over time, the researcher will receive multidisciplinary training in a highly collaborative and productive academic environment.
Duties and Responsibilities
70% Assistance with laboratory experiments and procedures
Prepare LB media, distilled Water, pipette tips and agar plates
Plasmid construction and isolation
Maintains cell line cultures and Plasmid transfection
Extract and quantify DNA from cell lines or animal tissue
Prepare samples for sanger sequencing
Perform and compile data related to molecular analyses including PCR, RT-qPCR, and western blots to evaluate mouse tissues
30% Laboratory organization
Ensure the hoods and benches are cleaned in accordance with the lab protocols
Maintain laboratory organization
Assist with mouse experiments
Performs preventative maintenance and record keeping procedures
Maintains appropriate workstation materials and inventory
Qualifications
All required qualifications must be included in the application materials
Required Qualifications
BA/BS, preferably in Biotechnology, Biological Sciences, Microbiology, Molecular Biology, or related disciplines; or a combination of related education and experience to equal four years
Laboratory experience in basic molecular techniques, e.g., Cell culture, PCR, WB, IHC, Plasmid construction and isolation
Ability to maintain and organized documentation of records of experimental work
Good working knowledge of MS Excel, Word, PowerPoint, as well as fluency in computer techniques and software for experimentation and analysis
Ability to self-motivate, multitask and make intellectual contributions to multiple projects.
Preferred Qualifications
Enthusiastic about science and its potential to make a difference for people
Runs RNA and protein assays with necessary troubleshooting
Demonstrates an understanding of the scientific principles of laboratory testing as well as the technical, procedural and problem-solving aspects
Assumes responsibility for good documentation practices and maintains clear and legible records
Benefits
Working at the University
At the University of Minnesota, you'll find a flexible work environment and supportive colleagues who are interested in lifelong learning. We prioritize work-life balance, allowing you to invest in the future of your career and in your life outside of work.
The University also offers a comprehensive benefits package that includes:
Competitive wages, paid holidays, and generous time off
Continuous learning opportunities through professional training and degree-seeking programs supported by the Regents Tuition Benefit Program
Low-cost medical, dental, and pharmacy plans
Healthcare and dependent care flexible spending accounts
University HSA contributions
Disability and employer-paid life insurance
Employee wellbeing program
Excellent retirement plans with employer contribution
Public Service Loan Forgiveness (PSLF) opportunity
Financial counseling services
Employee Assistance Program with eight sessions of counseling at no cost
Employee Transit Pass with free or reduced rates in the Twin Cities metro area
Please visit the Office of Human Resources website for more information regarding benefits.
How To Apply
Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume.
Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section.
To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-8647.
Diversity
The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.
The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu
Employment Requirements
Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment.
About the U of M
The University of Minnesota, Twin Cities (UMTC)
The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.
At the University of Minnesota, we are proud to be recognized by the Star Tribune as a Top Workplace for 2021, as well as by Forbes as Best Employers for Women and one of America's Best Employers (2015, 2018, 2019, 2023), Best Employer for Diversity (2019, 2020), Best Employer for New Grads (2018, 2019), and Best Employer by State (2019, 2022).
University Of Minnesota