Research Scientist Iii, Ivivp

Research Scientist III, IVIVP

Some opportunities happen only once in a lifetime - like a job where you have the chance to change lives. At Alexion, people living with rare and devastating diseases are our Guiding Star. We are driven to continuously innovate and create meaningful value in all we do to help patients and families fully live their best lives. We value the uniqueness and diversity of our employees and recognize that nurturing the diverse perspectives and strengths of our people translates into innovative breakthroughs for patients.

This Is What You Will Do

Alexion Pharmaceuticals is seeking a highly motivated and experienced scientist to join the Translation Biology group within the In Vitro and In Vivo Pharmacology (IVIVP) team. The Research Scientist III will represent IVIVP in cross-functional research teams to formulate experimental strategies, lead and design non-clinical proof of concept and IND-enabling studies internally/ externally to advance drug development projects for rare diseases. The role will mentor and work closely with junior scientists in a matrixed team environment. This position will also contribute to building new platforms and bringing in new technologies to expand IVIVP's capability to support Alexion's growing pipeline of rare disease therapies.

You Will Be Responsible For

• Serve as a subject matter expert in Nephrology/Cardiology/Immunology or related fields.

• Work closely with cross-functional groups including translational medicine, clinical and regulatory to support drug candidate evaluation, indication selection and life-cycle management. Propose and implement pharmacology research plans to generate decision-enabling data and reach project objectives.

• Lead the design and implementation of preclinical studies in relevant in vivo models. Develop and complete relevant downstream assays. Oversee the validity, analysis, reproducibility, and interpretation of data.

• Provide updates and communicate results with global project team, senior management, and stake holders with scientific presentations in research meetings.

• Work collaboratively in a diverse team matrix: train, mentor and motivates associates at different levels to support research activities.

• Manage activities and maintain external relationships with CROs, KOLs or other academic partners.

• Author technical reports and regulatory documents in support of IND/CTA applications.

• Implementing innovative solutions- acquire novel technologies and establish techniques to fill capability gaps and streamline research workflow.

• Work under limited supervision with a high level of autonomy

• Contribute to scientific publications, external presentations, and participation in professional conferences and working groups.

• Maintain highest standards of animal welfare and research data compliance

You Will Need to Have

• Ph.D. & minimum of 5-8 years postdoctoral or industrial experience, high-performing B.S. or M.S. candidates with 16+ years of research experience in a pharmaceutical and/or biotechnology setting may apply.

• In-depth experience and expertise in disease biology related to Nephrology/ Cardiology/ Immunology, as exemplified by outstanding peer-reviewed publications/patent records.

• Proficiency in evaluating, developing and implementing pharmacology models for preclinical studies (including but not limited to PK/PD, efficacy and proof-of mechanism)

• Proficiency in developing, implementing and providing trainings on broad range of in vivo/in vitro/ ex vivo assays, imaging modalities and quantitative analysis.

• Demonstrated critical thinking and analytical skills, ability to formulate original hypothesis, and design experiments to generate quality and conclusive data

• Experience collaborating with external partners (CROs/ academic laboratories).

• Exemplary multitasking and project management skills, thrive in a fast-paced matrix research environment; ability to understand business needs and prioritize resources efficiently

• Excellent communication skills to convey scientific information concisely and effectively.

• Strong interpersonal skills to work with interactive teams and adaptive to changes.

• Experience in training/mentoring; commitment to embrace a diverse, inclusive, and highly collaborative team culture.

• Strong attention to detail, competence to document and organize lab work in a compliant manner.

• Curiosity and self-drive to learn and expand existing skillsets; motivation to bring novel treatments to patients in need.

• This is an onsite role with mandatory presence at our New Haven headquarter.

Expectation of working in the office 4 days a week statement: When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of four days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.