Research Scientist, Exploratory Biology

Vertex Pharmaceuticals, Inc Boston , MA 02298

Posted 2 months ago

Job Description:

Vertex Pharmaceuticals Incorporated is offering an exciting opportunity for an exceptional Biologist to join our Exploratory Research team in Boston. We are seeking a highly motivated, independent scientist to identify novel pathways/targets to drive drug discovery research in genetically validated diseases. The scientist will also develop and implement novel assays and cellular models to interrogate these therapeutic targets. Vertex is a leader in specialty disease research, including cystic fibrosis, alpha 1 antitrypsin deficiency, sickle cell disease, genetic kidney disease, and others not yet publicly disclosed.

Key responsibilities:

  • Utilize modern molecular biology techniques to validate novel targets in severe genetic diseases with a high unmet medical need

  • Develop in vitro biochemical and cell-based assays aimed at discovering novel therapeutics

  • Independently design, perform, and direct key studies to understand the mechanism of action at the molecular and cellular level, and support drug discovery projects

  • Critically analyze and interpret complex data, and effectively document and communicate results to a variety of audiences

  • Work effectively with colleagues from cross-functional disciplines (chemistry, pharmacology, DMPK and toxicology).

  • Collaborate and deliver on objectives successfully in a fast-paced, highly-matixed work environment

Minimum Qualifications:

  • Ph.D. or (equivalent degree) in Cellular or Molecular Biology, Genetics, or Biochemistry and 0-5 years' post-doctoral experience in molecular biology, biochemistry and assay development

  • Skilled in molecular and cell biology techniques including, but not limited to, CRISPR/Cas9 gene editing, cloning, Western blotting, quantitative PCR, immunofluorescence techniques, or other techniques that would add value in new project identification and validation.

  • It is essential that the candidate possess strong communication and problem-solving skills, and have strong collaboration skills to be effective in a team environment focused on drug discovery

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at

icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Research Associate Cancer Biology Crispr

Monte Rosa Therapeutics

Posted 2 days ago

VIEW JOBS 5/6/2021 12:00:00 AM 2021-08-04T00:00 <p>We are seeking an energetic and self-motivated research associate to join a team of scientists working towards discovery of unique anti-cancer compounds for the treatment of targeted patient populations. Role requires experience in using CRISPR/CAS9 as a tool to develop novel cellular cancer models. The candidate will be a highly motivated experimentalist with a strong desire to succeed at the highest level.</p> <p><strong>Principal Duties and Responsibilities</strong></p> <p></p> <p>Engineer cell lines with knock-out or knock-in of genes of interest using non-intergrated sgRNA and CAS9</p> <p></p> <p>Design strategies for cloning fusion reporter gene vectors, identify CROs to perform cloning and manage execution of the work.</p> <p>Utilizes lasted Molecular biology tools to NGS,ddPCR rtPCR, advance cloning techniques Golden Gate, Gibson Assembly to build genomic knock up down models.</p><p><strong>Requirements</strong></p><p>BS/MS equivalent in cell/molecular biology, cancer biology or genetics with at least 1 year hands-on experience in cancer research preferably in a pharmaceutical setting</p> <p>Experience with molecular biology methods and assays such as molecular cloning, RNA and protein expression approaches (e.g. QPCR, Western blotting) as well as various genetic perturbation methods.</p> <p>Experience in gene editing using CRISPR/CAS9, particularly strategies that use non-interfated sgRNA and CAS9.</p> <p>Ability to maintain timely and detailed notes using electronic lab notebook as well as demonstrated experience using Microsoft Excel and GraphPad Prism </p> <p>Excellent interpersonal skills and willingness to learn a variety of new techniques and technologies; Ability to adapt to rapidly changing priorities and deadlines</p> Monte Rosa Therapeutics Boston MA

Research Scientist, Exploratory Biology

Vertex Pharmaceuticals, Inc