Research Scientist, Chemistry - Center For Protein Degradation

Dana-Farber Cancer Institute Boston , MA 02298

Posted 6 days ago

Overview

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities

Dana-Farber Cancer Institute (DFCI) and Deerfield Management have entered a multi-year collaboration to create the Center for Protein Degradation (CPD) at DFCI led by Drs. Fischer and Gray. The goals of the Center for Protein Degradation are to create a next-generation protein degrader platform and interrogate and advance a large portfolio of protein degrader targets. This is an exceptional opportunity to join a newly founded research center that is pushing the boundaries of targeted protein degradation research and accelerating the translation of basic science into clinical solutions.

The Center for Protein Degradation (CPD) is seeking an experienced medicinal chemist to join its team. This individual will be centrally involved in assisting various research projects primarily involving protein biochemistry. In addition to bench-based research, responsibilities will include laboratory management and organization. Training is available in all aspects of experimental research.

Responsibilities

  • Independently plan, manage, and perform experiments and chemistry projects. Develop project proposals, timelines, and resource needs. Monitor milestones and ensure deliverables are completed on time.

  • Develop novel chemistry methods to support Center projects

  • Design and execute multi-step organic syntheses to deliver biologically active small molecules

  • Plan and manage external research efforts with CROs and other collaborators

  • Collect and analyze experimental data and identify next steps based on outcomes

  • Train research technicians and other scientific staff in methods/techniques

  • Supervise scientific staff as needed

  • Interact with internal and external collaborators to advance projects

  • Prepare presentations and present project status and outcomes to Group Leads, Scientific Directors, and to external entities

  • Maintain clear and accurate records of experimental work (e.g., experiment methods, results/findings)

Qualifications

The CPD Research Scientist must fulfill the following requirements:

  • PhD in organic chemistry or similar discipline, with at least 3 years' post-doctoral experience. Industry experience preferred.

  • Experience leading complex research projects in medicinal chemistry is required.

  • Knowledge of research methodologies and emerging technologies such as: small molecular hits to leads trajectory, including HTS screening, medicinal chemistry, structural biology, proteomics, target ID, PK/PD, and ADME.

  • Skilled in use of chemistry lab equipment and experienced in relevant techniques NMR, LCMS, HPLC, flash chromatography

  • Management experience working with CROs preferred

  • Background/experience in oncology drug development is preferred

  • Excellent communication and presentation skills.

  • Scientific drive, demonstrated by a proven track record of publications in peer reviewed journals

  • Demonstrated ability to work in a fast-paced and dynamic environment.

  • Ability to work independently as well as in a collaborative and team environment

  • Proficiency in Microsoft Office

  • Excellent organizational and prioritization skills. Strong attention to detail

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.


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Research Scientist, Chemistry - Center For Protein Degradation

Dana-Farber Cancer Institute