Research Scientist 4

University Of Washington Seattle , WA 98113

Posted 2 months ago

As a UW employee, you will enjoy generous benefits and work/life programs. For a complete description of our benefits for this position, please visit our website, click here.As a UW employee, you have a unique opportunity to change lives on our campuses, in our state and around the world. UW employees offer their boundless energy, creative problem solving skills and dedication to build stronger minds and a healthier world.

UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits and natural beauty. All of which has allowed the UW to be nationally recognized as a "Great College to Work For" for four consecutive years.

The Department of Biochemistry at the University of Washington has contributed to many phases of research. Initially recognized for incisive studies of the structure and function of proteins, and the mechanisms of enzyme action, the department branched out into a multitude of other areas.

These included: developmental biology of flies, fish, frogs, and mice; molecular mechanisms of aging in yeast and mammals; vertebrate visual and immune responses; chromosome dynamics, cell division, DNA replication and repair; energy transduction during photosynthesis; protein secretion and membrane fusion; translational control and regulated protein degradation; protein structure determination by crystallography and NMR spectroscopy; and protein structure prediction and enzyme design. Our diversity of interests guarantees a rich intellectual and educational environment.

The Department of Biochemistry currently has an outstanding opportunity for a RESEARCH SCIENTIST ENGINEER 4.

Collaborate with the Investigator and numerous researchers at the Institute for Protein Design on the X-ray crystal structure determination of de novo designed proteins.

Manage the activities of research scientists and undergraduate research support with oversight of all protein-to-structure activities at the Institute for Protein Design.

Design of new concepts, approaches and programs for structure determination of computationally designed proteins, of a diverse nature.

Perform various specialized scientific investigative procedures in X-ray structure determination and computational protein design in collaborative support of numerous research projects with minimal input from Investigator.

Use bio-informatics tools and pertinent laboratory and public databases, including the Protein Data Bank (PDB), and information resources to support gene-to-structure research, including deposition of atomic coordinates in the PDB for archival, sharing, and publication.

Directs the activities of technical support staff in the Baker lab and at the Institute for Protein Design in collaboration with other research staff.

Collaborates with other research staff, postdoctoral fellows and graduate students to select and maintain relevant protein research equipment to insure the lab meets required current and future needs.

Directs the development of new protein crystallization and X-ray structure determination strategies, and ascertain if they effectively addresses needs.

Manages complex multi-task projects directed at the design, production and structural characterization of numerous de novo designed proteins with higher order function.

Trains, and trains others in how to train, laboratory research staff, postdoctoral fellows and graduate students in protein X-ray crystallography, use of Rosetta software and protein design computing infrastructure, as well as wet lab equipment for protein production, structural elucidation, and biochemical characterization.

Directs projects with undefined time lines and uncertain outcomes requiring analysis from multiple perspectives.

Use expert knowledge and judgment to develop new methods and techniques for obtaining solutions.

Minimum Requirements:

Ph.D in Biochemistry/Protein Design and X-ray Crystallography +5 or more years of related experience

Technical proficiency, scientific creativity, collaborative ability as well as independent thought.

Advanced expertise in protein design research and protein X-ray crystal structure determination, both computational and wet lab areas, with a full understanding of the underlying principles and concepts. May be recognized as a leader in their area of expertise.

Recognized as a resource for others to use in dealing with complex protein structure determination, computational and wet lab methods, equipment, processes, or procedures. Anticipates future needs in technology support.

In-depth understanding of organizational structure both within and outside the work unit, including the role of each position in the group and in other groups.

Ability to develop innovative processes to achieve goals. Directs others to develop essential tasks. Reviews work activities to determine where new information could improve processes or move projects forward.

Proficient in Rosetta computational protein design and wet lab protein-to-structure research.

Desired:

Ph.D. degree in an appropriate field of science or technology or equivalent in education and experience AND total of six year's research experience in protein biophysics, X-ray crystallography, computational biology and bioinformatics specifically in the X-ray crystal structure determination of de novo designed proteins and the development of Rosetta algorithms and wet lab methods for computational design of small molecule ligand binding proteins.

Application Process:

The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others.

Any assessments that you need to complete will appear on your screen as soon as you select "Apply to this position". Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your "My Jobs" page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.



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Research Scientist 4

University Of Washington