Research Leader

Hoffmann-La Roche Inc. Santa Clara , CA 95051

Posted 5 months ago


This position will lead sample library prep for the nanopore sequencing team.


  • Responsible for development of novel library prep strategies for Roche nanopore sequencer and optimization of library prep construction, purification and characterization.

  • Develops product concepts and specifications, and translates into focused scientific activities.

  • Plans and designs advance independent or multi-disciplinary research/development experiments driven by strategic business needs.

  • Serves as subject matter expert with external resources and contacts at various management levels concerning operations or scheduling of specific phases of projects.

  • Prepares timelines and assessments of project progress and critical factors, and establishes priorities.

  • Assumes responsibility for timely completion of projects, and resolves technical issues.

  • Ensures activities meet performance/quality expectations and are consistent with project critical path.

  • Ensures technical activities under delegated supervision are conducted within of internal and external guidelines and regulations. Interacts with other departments to further project goals.

  • Recommends new approaches, expansion or curtailment of project technical activities based on experimental results or new scientific information.

  • Adjusts direction of research activities accordingly as scientific findings warrant.

  • Communicates progress of efforts to Director and other departments to assure awareness of current status of projects.

  • Provides top line review of experimental results, and secondary review of experimental data.

  • Presents findings or comprehensive project status reviews at internal & external meetings.

  • Manages projects and assigned staff, provides scientific/technical direction, and designates accountability for product research and development activities. Gives people assignments and training to develop their abilities.

  • Makes decisions under consultative direction that impact broad company objectives.

  • Decisions have a long term effect on the objectives of the function and/or area.

  • Manages staff; provides staff with coaching, training and opportunities to develop skills, and gives ongoing, constructive and timely feedback on performance and progress toward goals and expectations.


  • Master's degree in Biological/Life Sciences, Chemistry, Biochemistry or related field and 8+ years industry experience or Ph.D. and 5+ years of industry experience

  • Expert in enzymatic manipulation of DNA, DNA amplification, genomic DNA library prep, DNA sequencing, polymerase chain reaction, and other standard Molecular Biology techniques.

  • Expert in oligonucleotide characterization, probe/primer designs, generation, and hybridization

  • Detailed-oriented, analytical and systematic in problem-solving and trouble-shooting.

  • Prior experience with next-generation sequencing sample prep is strongly preferred.

  • Knowledge of structural biology and biophysics of nucleic acids and nucleic acid-protein interactions preferred.

  • Knowledge of bioinformatics preferred.

  • Prior experience with single molecule sequencing preferred.

  • Prior leadership and management preferred.

Roche is an equal opportunity employer.

Research & Development, Research & Development > Research

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Research Leader

Hoffmann-La Roche Inc.