The Department of Molecular Physiology and Biological Physics at the University of Virginia invites applicants for a Research Instructor position in Dr. Avril Somlyo's Smooth Muscle Somlyo Laboratory.
The NIH research focuses on the discovery of the contribution and the mechanism of action of our recently identified p90 ribosomal S6 kinase to the maintenance of basal tone, contractility and hypertension when activated by agonists and increased vascular intraluminal pressure. Outcomes will lay the groundwork for the future development of pharmaceuticals to treat smooth muscle-based diseases and will also increase our basic understanding of smooth muscle contractility.
The Research Instructor will be responsible for the development of hypotheses, study design, performance of studies, data analysis and manuscript preparation. Experience with contractility measurements of isolated or permeabilized blood vessels from normal and transgenic mice following neurohumoral or mechanical stimuli or following the introduction of activatory or inhibitory peptides is essential.
A preference will be given to candidates with experience in pressure myography of arteries; biochemical assays to identify signaling pathways including gel electrophoresis, western blotting, immuno-precipitation, Bio-Id, kinase assays; immuno-histochemistry and confocal microscopy; live cell imaging of Ca2+, pH in resistance vessels; molecular biology and cell culture skills including cell transfection of cells and blood vessels using adenoviral constructs to silence proteins of interest. As well, experience with mouse husbandry is preferred.
Education; Ph.D. or terminal degree
This is a restricted position; continuation is dependent on funding and satisfactory performance.
Review of applications will begin on November 28, 2019, but the position will remain open until filled.
EXTERNAL APPLICANTS: please apply through Workday at the following URL, https://uva.wd1.myworkdayjobs.com/UVAJobs, and search for requisition # R0011728. Complete an application online and attach a cover letter, CV/resume, and contact information for three references (name, email address, telephone number, address). Please note that multiple documents can be uploaded in the box. The successful candidate will pass a criminal background check.
INTERNAL UVA APPLICANTS: please apply through your Workday Home page, search "Find Jobs", and search for requisition # R0011728. Complete an application online and attach a cover letter, CV/resume, and contact information for three references (name, email address, telephone number, address). Please note that multiple documents can be uploaded in the box. The successful candidate will pass a criminal background check.
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