Dana-Farber Cancer Institute Boston , MA 02115
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
The Spektor Laboratory at the Dana-Farber Cancer Institute/Harvard Medical School in Boston, MA is looking for an exceptional post-doctoral candidate interested in studying the mechanisms underlying genome evolution during tumorigenesis and in therapy resistance. Using a comprehensive approach that combines cell biological, biochemical and genomic methods, our laboratory seeks to address many longstanding questions in cancer genome evolution. For instance, we are interested in understanding how genomes evolve following exposure to ionizing radiation, leading to therapy resistance and secondary malignancies. We additionally aim to exploit cancer-specific vulnerabilities, such as the recent finding that cancer cells exhibit nuclear envelope fragility, as potential therapeutic strategies. In our studies, we employ a recently developed Look-seq approach that combines live-cell imaging and single-cell whole genome sequencing, enabling us to directly relate phenotypes observed under the microscope to their genomic consequences.
The Post-doctoral fellow will be part of a rich intellectual and collaborative environment and will have access to state-of-the-art facilities within the laboratory, the Dana-Farber Cancer Institute, Harvard Medical School, and other top academic institutions across the Boston Area.
Desired Skills and Experience
The candidate should have recently received a Ph.D. in molecular or cell biology, biochemistry or a related field. A successful candidate will be highly motivated, independent yet willing to collaborate with other team members and eager to develop and pursue a novel research program. * A strong background in molecular biology, cell biology, biochemistry, cancer biology
Prior scientific accomplishment with at least one first author peer-reviewed publication
Proficiency in English communication (both written and oral)
Additional Preferred Skill Sets
A strong background in microscopy and image analysis OR
A strong background in genomics and bioinformatics
Please apply with your cover letter and CV, including e-mail and phone contact information for 2-3 references, to .
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.