Research Associate/Associate Scientist, Biology

About Ratio Therapeutics

Ratio Therapeutics is committed to improving and extending the lives of cancer patients without sacrificing their quality of life. We are a team of passionate scientists, engineers, and business professionals dedicated to advancing the field of targeted radioligand therapy. To accomplish this, we utilize our proprietary TRILLIUM and MACROPA platforms: TRILLIUM allows fine-tuning of radioligand pharmacokinetics thereby enhancing the therapeutic index, while MACROPA simplifies the manufacturing process for the alpha-emitting isotope, actinium-225. These platform technologies have resulted in an emergent pipeline of novel therapeutic candidates. We are looking for talented, dedicated, and creative individuals eager to help us advance these technologies from discovery research through clinical development. Join us in our quest to become the leading innovator in radioligand therapy and improve the lives of cancer patients and their families.

About the Position

Ratio is seeking a highly motivated and skilled Research Associate/Associate Scientist in Biology to join a growing team of multidisciplinary scientists responsible for driving preclinical discovery efforts. The successful candidate will have strong interest and expertise working within preclinical oncology and pharmacology, with a well-rounded understanding of cancer biology and drug discovery techniques towards target ID and drug discovery and development. The candidate will execute studies to advance preclinical biology and pharmacology in vitro, in vivo and ex vivo and effectively communicate their data. The ideal candidate will enjoy working in a collaborative, fast-paced, multidisciplinary environment and be skilled at independently executing studies.

Key Responsibilities

• Design and execute biochemical assays for compound characterization.

• Conduct mammalian cell culture and execute cell-based experiments for lead discovery and optimization.

• Design and execute a range of ex vivo tissue-based experiments including histological, immunohistochemical and radiological to monitor and pinpoint organ and cellular biodistribution of candidate molecules.

• Execute in vivo pharmacology studies in cell line and patient-derived xenografts for compound evaluation.

• Follow developed protocols and work with team to refine/advance new protocols and workflows.

• Assist in management of day-to-day laboratory operations including maintenance of equipment, as well as reagent tracking, ordering, and receiving.

• Analyze data, troubleshoot experimental issues, and summarize key findings.

• Communicate results effectively with internal stakeholders and align on future directions.

• Demonstrate experience working collaboratively within and across teams in a complex, matrix environment.

• Demonstrate strong interpersonal, organizational skills and leverage team work to create innovative solutions and achieve common goals.

• Continually learn and deepen his/her expertise in Radiopharmaceutical therapies and cancer biology.

Qualifications

• Bachelor's/Master's degree in biochemistry/cell biology, pharmacology, cancer biology, pathology or a related field with 2+ years of industry experience.

• Hands-on experience in a wide range of in vitro, ex vivo, and in vivo techniques is preferred, with core competency in pharmacology, in vitro cell biology and/or in vivo pharmacology.

• Familiarity with or use of radioactivity or radioactive assays a plus.

• Excellent problem-solving skills, an attention to detail and able to work independently with minimal supervision

• Ability to communicate candidly and openly.

• Demonstrated pursuit of quality and excellence in innovation and execution.

• Exhibit integrity, respect, and compassion for colleagues, collaborators, and the patients we serve.