Acceleron Pharma Cambridge , MA 02138
Who are we?
Acceleron is a Cambridge-based, clinical-stage biopharmaceutical company dedicated to the discovery, development, and commercialization of therapeutics to treat serious and rare diseases. The Company's leadership in the understanding of TGF-beta biology and protein engineering generates innovative compounds that engage the body's ability to regulate cellular growth and repair.
Acceleron focuses its research and development efforts in hematologic, neuromuscular, and pulmonary diseases. In hematology, the Company and its global collaboration partner, Celgene, are developing luspatercept for the treatment of chronic anemia in myelodysplastic syndromes, beta-thalassemia, and myelofibrosis. Acceleron is also advancing its neuromuscular franchise with two distinct Myostatin
What's in it for you?
As a member of the protein purification team, you will be responsible for the purification of a diverse assortment of proteins varying from untagged proteins to fusion proteins and antibodies. The candidate will also be responsible for providing protein chemistry support including production, labeling and characterization of reagents for the R&D department as well as other groups in the organization. If you are motivated to tackle multiple targets, each with unique challenges, and driven to solve problems by employing intellectual flexibility, then this role could be a great fit for you!
What will you do?
Purify and characterize fusion proteins and antibodies for the R&D pipeline in both small and large scale amounts
Perform stability and pre-formulation studies on purified proteins
Generate and provide protein reagents to other departments in the company and to collaborators
Present reports and results at various meetings, both internally and externally to collaborators and at conferences
What are we looking for?
B.S. in Biochemistry, Chemistry or related fields with 1-3 years of relevant protein purification and/or characterization experience that could include a co-op or internship
Demonstrated proficiency in various techniques of protein purification such as affinity, ion exchange and gel filtration chromatography
Experience in purification of antibodies and receptor-fusion proteins is highly desirable
Experience with protein characterization techniques such as SDS-PAGE, IEF/cIEF, Western blot, SEC, DSF and RP-HPLC is a plus
Experience with protein labeling is a plus
Efficient time management and ability to work on several projects simultaneously are essential. Strong interpersonal skills and ability to collaborate and communicate with a wide variety of people is a must
How will you grow with us?
As a part of the Protein Purification team, you will be able to contribute to a variety of exciting projects in a dynamic and fast-paced environment. We welcome fresh ideas and encourage new initiatives that will help us achieve our goals. At Acceleron, it is not just the 'what you do' that is important, but also the 'how you do it.' The Protein Purification group works hard to succeed, but they also support one another along the way. Take a step toward developing your career and join our fun and passionate Protein Purification team!