Research Associate Oligonucleotide Synthesis

Dicerna Pharmaceuticals, Inc. Cambridge , MA 02138

Posted 5 days ago

Posted November 2, 2018

Dicerna Pharmaceuticals is seeking highly motivated scientists to join its oligonucleotide/medicinal chemistry team in Cambridge, Massachusetts. The candidates will be responsible for the synthesis, deprotection, and purification of oligonucleotides, and the analysis and characterization of oligonucleotides. This position will support therapeutic programs in multiple disease areas and will contribute to the development of novel nucleic acid conjugate platforms. Prior experience in oligonucleotide synthesis and characterization is desired but not required.

Key Responsibilities:

  • Synthesis of oligonucleotides, deprotection, purification, annealing and lyophilization of oligonucleotides to support all disease programs

  • Analytical characterization of the synthesized oligonucleotides for purity determination and impurity profiling

  • Support new chemistry discovery for the development of novel oligonucleotide conjugate platforms

  • Operate, maintain, and troubleshoot lab instruments such as oligonucleotide synthesizers, purification systems, HPLC and LC-MS

  • Conduct laboratory work in safe, efficient manner that ensures a safe working environment for colleagues

  • Ability to complete assignments and meet deadlines and time schedules

  • Keep accurate record of the experiments and summarize the results in written reports

  • Possess excellent written and verbal communication skills

  • Demonstrate an ability to work as part of a team and possess an excellent work ethic

  • Ability to be successful in a fast-paced, intense work environment


  • PhD in Chemistry or related field with 1-2 years of industrial experience, or MS with at least 3 years of industrial experience, or BS with 5 Years

  • Strong knowledge of nucleic acids chemistry, oligonucleotide synthesis, deprotection and purification techniques

  • Experience with oligonucleotide synthesizers preferred

  • Experience with analytical techniques e.g. RP-UPLC, SAX-HPLC, LC-MS and data interpretation

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Research Associate Oligonucleotide Synthesis

Dicerna Pharmaceuticals, Inc.