Research Associate In Cell Biology

Yale University New Haven , CT 06501

Posted 3 months ago

Essential Duties

Principal Responsibilities:

1.Recommends the design and implementation of procedures and protocols under the direction of a higher-level authority. 2. Investigates, analyzes, and reaches preliminary scientific conclusions related to research planning 3. Ensures data results are compiled, analyzed, and presented properly. 4. Analyzes, develops and interprets scientific results. Maintains clear documentation of results. Prepares scientific reports and papers for research proposals and published reports. 5. Performs independent research and laboratory techniques and participates in experimental research planning. 6. Interacts with internal contacts including the PI, research assistants, graduate students, Radiation Safety and Biological Safety officers, and Animal Care personnel to discuss and evaluate research results and to ensure the smooth and safe operation of the laboratory. 7. Interacts with external contacts such as researchers at other institutions, staff at biotechnology and reagents companies to consult on research methods and to keep abreast of product information and developments. 8. May perform other duties as assigned.

Required Education and Experience

Required Education and Experience:

Master's Degree in a scientific discipline and one year experience or an equivalent combination of education and experience.

Background Check Requirements

All candidates for employment will be subject to pre-employment background screening for this position, which may include motor vehicle, DOT certification, drug testing and credit checks based on the position description and job requirements. All offers are contingent upon the successful completion of the background check. Please visit for additional information on the background check requirements and process.

Position Focus:

Under the direction of the Principal Investigator and working in collaboration with laboratory personnel, this position will collect, analyze and present findings regarding neurodevelopmental events in C. elegans embryos, including preparation of scientific reports and papers for research proposals and published records. The position will also create nematode transgenic strains through microinjection, and organize freezing, storing and managing the laboratory transgenic nematode strains.

The position will also interact with external contacts such as researchers from other institutions and vendors to consult research methods and assist in the ordering and organization of lab reagents. Advanced knowledge in C. elegans husbandry, genetics and imaging, and in molecular biology, a plus.

Preferred Education, Experience and


Expertise in either worm husbandry, molecular biology, C. elegans transgenics, microscopy and imaging or micro injections a plus.

Posting Disclaimer

The intent of this job description is to provide a representative summary of the essential functions that will be required of the position and should not be construed as a declaration of specific duties and responsibilities of the particular position. Employees will be assigned specific job-related duties through their hiring departments.

Affirmative Action Statement:

Yale University considers applicants for employment without regard to, and does not discriminate on the basis of, an individual's sex, race, color, religion, age, disability, status as a veteran, or national or ethnic origin; nor does Yale discriminate on the basis of sexual orientation or gender identity or expression. Title IX of the Education Amendments of 1972 protects people from sex discrimination in educational programs and activities at institutions that receive federal financial assistance.

Questions regarding Title IX may be referred to the University's Title IX Coordinator, at, or to the U.S. Department of Education, Office for Civil Rights, 8th Floor, Five Post Office Square, Boston MA 02109-3921. Telephone: 617.289.0111, Fax: 617.289.0150, TDD: 800.877.8339, or Email:

upload resume icon
See if you are a match!

See how well your resume matches up to this job - upload your resume now.

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Research Investigator/Sr Research Investigator Platform Biology

Arvinas, Inc.

Posted 1 week ago

VIEW JOBS 1/10/2019 12:00:00 AM 2019-04-10T00:00 Arvinas is a pharmaceutical company focused on developing new small molecules ‒ known as PROTACs (PROteolysis TArgeting Chimeras) ‒ aimed at degrading disease-causing cellular proteins via proteolysis. Based on innovative research conducted at Yale University by Dr. Craig Crews, Founder and Chief Scientific Advisor, the company is translating natural protein degradation approaches into novel drugs for the treatment of cancer and other diseases. The proprietary PROTAC-based drug paradigm induces protein degradation, rather than protein inhibition, using the ubiquitin proteasome system and offers the advantage of potentially targeting "undruggable" as well as "druggable" elements of the proteome. This greatly expands the ability to create drugs for many new, previously unapproachable targets. For more information, visit Position Summary Your focus will be to build innovative in vitro assay approaches to investigate mechanisms of protein degradation. As one of the key hires for the company, you will work in close collaboration with leaders and scientists to ensure that our platform technology evolves based on a rigorous scientific foundation. Our aim is to further understand the underlying principles of PROTACs and continue to evolve our protein degradation platform in areas of high unmet medical need including cancer and neurodegeneration. Principal Responsibilities * Application of strong expertise in molecular biology, cell biology, drug discovery approaches and biochemical and biophysical techniques to study PROTAC engagement of the ubiquitin proteasome system, or targeted protein degradation * Strength in executing and evaluating experiments to measure target engagement, protein degradation, pathway modulation and therapeutic sensitivity in response to compounds to develop structure-activity relationships * Experience in developing assays to profile compounds using mechanistic and functional readouts (intracellular binding approaches, bioluminescence (nanoBRET), fluorescence (FRET), High Content Imaging- a plus) * Strong expertise in molecular biology using siRNA/ ASOs, CRISPR knock out and mutagenesis strategies, and generation of relevant cell models to study targeted degradation in disease context. * Demonstrated success in working on a cross-disciplinary, drug discovery project team; integrating and evaluating the work of multiple drug discovery groups / functions * Expertise in developing compound profiling assays to support chemistry efforts in developing structure-activity relationships * Excellent communication and interpersonal skills * Supervisory experience Qualifications * PhD, with 5+ years of pharma/ biotech/ academic experience in cellular and molecular biology, pharmacology, biochemistry, biophysics or enzymology. Focus on cancer cell biology and drug discovery strongly preferred. * Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills and demonstrated ability to advance new scientific understanding * Experience in the ubiquitin-proteasome system, or targeted protein degradation, preferred * Manages times and balances work between bench and desk * Maintains accountability for ensuring own goals, those of any direct reports and company objectives are achieved * Proficient Data with data analysis tools (PRISM, Spotfire/Vortex, Matlab, etc. a plus) * Maintains a safe working environment for self and others * Represents the company effectively to external organizations and to the Board of Directors and other company senior management, as needed/requested * Writes procedures/protocols and professional/technical reports and writes scientific articles, publications and patents Education * Ph.D. Please send CV and cover letter to: Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit Arvinas is an Equal Opportunity employer Arvinas, Inc. New Haven CT

Research Associate In Cell Biology

Yale University