Manager: Scientist II
Sangamo Therapeutics is a genomic medicine company building value with cutting-edge work across four distinct but complementary technology platforms - gene therapy, cell therapy, in vivo genome editing, and in vivo genome regulation. At Sangamo, we are passionate in developing genomic medicines to transform the lives of patients with serious diseases. We transform lives by building a robust, sustainable, differentiated, innovative, and high value genomic medicine pipeline that addresses patients with life-limiting conditions. Sangamo takes pride in being the first to edit endogenous human genes, first to treat patients with gene edited T cells, and first to treat patients with in vivo genome editing. Our top priority is to meet the needs of patients with commitment and compassion. Sangamo is a company where individuals can flourish, grow and develop their expertise.
We are seeking top talent to join our team. Let's build a better future together.
Sangamo Therapeutics is seeking a talented Research Associate in our Discovery and Translational Research group to support the development of our novel ZFP-TF platform for the treatment of CNS diseases.
The successful candidate will work within Discovery and Translational Research and contribute to the development of novel CNS therapeutics. Key responsibilities will include performance of neuronal cell culture experiments to demonstrate target engagement and support lead candidate selection, screening and assay development, and generation of data from in vivo studies to support advancement of CNS programs. The position requires adaptability, creativity, good written and verbal communication skills, as well as a capacity for constant innovation in pursuit of company goals. The environment is exciting and fast-paced, and offers the opportunity to work and publish at the cutting edge of genome engineering research and translational medicine.
Perform in vitro experiments in primary and iPSC-derived neurons
Perform chronic AAV expression studies in mammalian cell models
Expertise in molecular and biochemical methods (qRT-PCR, ELISA)
Process animal tissue for RNA, DNA, and protein endpoints
Successfully plan, execute, and document laboratory procedures and experiments with great attention to detail
EDUCATION, EXPERIENCE AND SKILLS REQUIREMENTS:
B.S. or M.S. in molecular and/or cellular biology, biochemistry, neuroscience, bioengineering, chemical engineering, or related discipline
4+ years of relevant laboratory experience in an academic research laboratory or biotechnology company. Level will be determined by education, experience, and skills
Experience with neuronal cell culture, including AAV and nucleic acid transfection
Extensive experience with molecular biology and biochemical methods and techniques including qRT-PCR, ELISA, western blotting, and nucleic acid and protein isolation from mammalian cells and animal tissues
Preferred candidates will be proficient in use of the Microsoft Office Suite and statistical analysis and graphing software (e.g. GraphPad Prism, SigmaPlot)
Strong experiment design, problem-solving, and data analysis skills are desired
Excellent communication and presentation skills
Experience with high-throughput assays preferred
Experience with gene therapy and CNS-related fields preferred
Sangamo is an equal opportunity employer
The above reflects management's definition of essential functions for this position but does not restrict the tasks that may be assigned. The above duties are representative only; management may assign or reassign duties and responsibilities to this position at any time.
Sangamo Biosciences, Inc.