Research Associate II, Translational

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45 and 50 skipping amenable. We have also partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You should be versatile, self-motivated, and eager to roll up your sleeves, as a member of the product development team. You should enjoy a fast-paced environment and feel comfortable juggling competing priorities. You work successfully in a team environment with strong interpersonal skills to effectively build working relationships inside and outside the company.

The Opportunity

In this role, the ideal candidate will support data generation and analysis of therapeutic candidates for regulatory submissions and work collaboratively to coordinate in vitro and in vivo studies. They will be responsible for data generation, data integrity, and data quality control. They will work side-by-side with chemistry, pharmacology, neuromuscular, and analytical team members to support pre-IND and IND enabling studies. The ideal candidate will coordinate with local or international CROs and consultants to support pre-IND and IND enabling studies. Additionally, they will have the opportunity to contribute to scientific publications and regulatory submissions as needed.

Responsibilities

• Generate data from in vitro and in vivo samples to support pre-IND and IND-enabling studies.

• Coordinate the design of in vitro and in vivo studies for clinical candidates.

• Coordinate with discovery and neuromuscular teams for method, data, and sample transfers.

• Organize and document all experimental data and connect with all related in vitro and in vivo IND-enabling studies.

• Contribute to patents, reports, and scientific publications as required. During internal and external meetings, you should be ready to interpret and present research data and findings.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

• Humanity

• We genuinely care about patients and about one another.

• Tenacity

• We are relentless and persistent in the pursuit of developing therapies for patients.

• Creativity

• We are creative problem solvers.

• Collaboration

• We are more than the sum of our parts.

• Curiosity

• We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

• A BS/MS in biological sciences or a related field with a minimum of 2 years of wet lab experience in an academic or industry environment.

• Experience with RNA and protein extraction and digital droplet PCR (ddPCR) is highly valuable with other molecular biology techniques including Jess Simple Western and plate-based assays is a plus.

• Experience with pre-clinical in vitro and in vivo work is a plus.

• Excellent working knowledge and familiarity with Microsoft Office.

• Excellent verbal and written communication skills.

• Ability to work effectively across functions and teams.

• Ability to work in a highly dynamic environment, innovative, and collaborative environment.

The Perks

By becoming a team member here at Entrada, you'll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

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