Research Associate, Biochemistry

California Life Company San Francisco , CA 94118

Posted 2 months ago

Who we are

Calico is a research and development company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan. We will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Executing on this mission will require an unprecedented level of interdisciplinary effort and a long-term focus for which funding is already in place.

Position description

The Biochemistry group at Calico is seeking a motivated and experienced Research Associate to join our team. The successful candidate will join a multi-disciplinary team focused on elucidating the biochemical properties/structures of proteins relevant to human aging. The ideal candidate must be highly motivated, detail-oriented, work autonomously with a variety of techniques, and comfortable presenting results to cross-functional teams.

Position requirements

  • BS/MS in biochemistry or related discipline plus 3+ years technical experience

  • Expression of proteins in mammalian/bacteria/yeast systems for research and early stage screening work

  • Hands on experience of common strategies of protein purification. Extensive experience with AKTA purification systems

  • Proven track record on structural biology studies such as X-ray crystallography and cryo-EM is highly desired

  • Mastery of molecular cloning, construct design and optimization

  • Mammalian cell line maintenance, stable cell line development, and transfection

  • Demonstration of accountability, ability for multitasking, and attention to detail

  • Strong teamwork and communication skills

  • Self-motivation and a "can-do" attitude will be needed to succeed in this fast-paced team

icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Senior Scientist Biochemistry South San Francisco CA

Johnson & Johnson

Posted 7 days ago

VIEW JOBS 10/10/2019 12:00:00 AM 2020-01-08T00:00 At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow us @JanssenGlobal. Janssen BioPharma Inc. is part of the Janssen Pharmaceutical Companies. The Biochemistry group within Infectious Diseases Discovery in Janssen BioPharma Inc. is seeking a Senior Scientist to join our efforts in the discovery of novel therapeutic agents. You will join a team whose focus is the development of new biochemical assays, production, and characterization of target proteins, screening of potential drug candidates against the infectious disease targets and performing studies on the mechanism of action of novel compounds. DUTIES AND RESPONSIBILITIES: * Provide biochemistry leadership to multi-disciplinary project teams in the discovery and optimization of drug candidates * Innovate biochemistry exploratory research by identifying and characterizing new molecular targets for novel therapeutic interventions * Advance drug discovery by performing and managing the cloning of target genes, expression, purification and characterization of recombinant target proteins to supply high-quality materials for exploratory research and compound profiling * Develop and implement novel enzymatic and biophysical assays to support compound profiling and MOA studies * Analyze, interpret and present data to group members, multi-disciplinary project teams and senior management teams * Work with external collaborators and contractors (CROs) to extend our protein science research capability * Author internal reports and external publications * Share results, skills, and knowledge in a team-based environment * Maintain timely and accurate lab records. Follow all Environmental, Health & Safety laboratory safety standards and maintain company compliance requirements Qualifications REQUIRED SKILLS AND EXPERIENCE: * Ph.D. in Biochemistry, Biophysics, Molecular Biology, or related disciplines, with 2+ years of post-doc or industry experience. * Expertise in designing protein expression constructs for baculovirus/insect cells and bacteria * Expertise in purifying protein with various separation methods including Ion exchange, affinity, and SEC * Proficiency with protein analysis techniques (e.g. SDS-PAGE, Western blotting, Bradford, and protein ID with MS) * Must have excellent interpersonal skills with the ability to interact effectively with people * Must have the ability to clearly and effectively present scientific data and concepts to colleagues and teams PREFERRED SKILLS AND EXPERIENCE: * Expertise in designing protein expression constructs for mammalian cells is preferred * Proficiency with protein purification using the ÄKTA chromatography system is preferred * Experience with protein characterization with biophysical methods (e.g. DLS, DSF, SPR, crystallography, and cryo-EM) is desirable * Experience with steady-state and pre-steady-state enzymatic assays is desirable * Experience in high-throughput assay development using fluorescent, radiometric and other detection technologies is desirable Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. Primary Location United States-California-South San Francisco- Organization Janssen BioPharma, Inc. (6224) Job Function Biology Requisition ID 4874190916 Johnson & Johnson South San Francisco CA

Research Associate, Biochemistry

California Life Company