The Hackensack Meridian Health Center for Discovery and Innovation is offering a position for postdoctoral studies in the field of hematopoiesis and regenerative medicine in the laboratory of Dr. Jason Butler.
The long-term goal of the laboratory's research program is to unravel the mechanisms by which supportive niche cells promote organ regeneration in the hope of translating these therapeutic modalities to repair injured organs. The Butler laboratory focuses on enhancing regeneration of the hematopoietic system in the context of hematological injuries (e.g. myelosuppression), leukemogenesis, and aging. The laboratory's commitment to studying the hematopoietic system is based on the laboratory's discoveries demonstrating that bone marrow endothelial cells (BMECs) serve as instructive niche cells that are essential for the reconstitution of the hematopoietic system following radiation injury.
The concept that BMECs provide an instructive fertile niche for maintenance of functional HSCs opens up new avenues for many aspects in stem cell biology and can be applied to multiple biosystems. The successful postdoctoral candidate will have a strong interest in microenvironmental control of hematopoietic and leukemic stem cell self-renewal and differentiation. The candidate will perform in vivo animal models and in vitro analyses.
The postdoctoral fellow is expected to understand the project and work independently taking responsibilities in the development and execution of experimental procedures to successfully advance the research project. The successful candidate will be responsible for preparing data for presentations, progress reports, and the preparation of manuscripts and posters. The post-doctoral fellow is anticipated to have good communication and writing skills. The successful candidate will have a team-oriented mindset and will provide guidance to junior members.
Responsibilities Proficient at most gold standard assays to test hematopoietic function. Establish sensitive and reproducible procedures for detection of endothelial derived angiocrine factors.
Design and conduct animal studies using a vast array of genetic models. Perform data analysis and interpretation. Present results in internal and external research forums.
Participate in grant and manuscript writing, as appropriate. Qualifications Hold a Ph.D. in Stem Cell Biology/Regenerative Medicine, Molecular Biology, or equivalent from an accredited graduate level institution. Minimum publication or in preparation of one article as first author in a reputable peer-reviewed scientific journal.
Excellent analytical and presentation skills. Expertise in cell culture, flow cytometry, mouse handling, and basic cellular and molecular biology techniques required.
Hackensack University Medical Center