Protein Sciences, Car-T Cell Engineering - Intern

Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world.

Whether it's the biological diversity of our gene editing systems or the people that help discover them, Metagenomi celebrates the diversity of life. This is achieved through a compassionate culture that acknowledges the dimensions of our diversity. We know that when people feel a sense of inclusion and belonging in the workplace, they have a safe space to bring creativity and innovation to everything they do. We are intentional about building and maintaining a culture where people are valued and respected, there is equity in opportunities, and our respective opinions and differences matter.

Application Guidelines:

• Resume: Highlight relevant coursework, laboratory experience, and relevant technical skills

• Cover Letter:

• Briefly outline why you are interested in this internship specifically.

• Connect 2-3 of your strongest skills directly to the responsibilities outlined in the job posting.

We're seeking a motivated summer intern to join our Protein Sciences team, playing a vital role in advancing the design and development of novel chimeric antigen receptors (CARs) for our cutting-edge CAR-T cell programs.

The Opportunity:

• Design and create innovative CAR templates to enhance cell therapies

• Master molecular cloning techniques, including PCR preparation, bacterial transformation, and plasmid purification.

• Verify correct cloning through sequencing analysis.

• Prepare lentiviral vectors for CAR-T cell transduction.

• Directly evaluate the performance and functionality of engineered CAR-T cells.

How You'll Contribute:

Your work will directly support the creation of next-generation CAR-T therapies, potentially leading to groundbreaking treatment options for patients.

What You'll Bring:

• Education: Actively pursuing an advanced degree in Biochemistry, Molecular Biology, Cell Biology, or a closely related field.

• Knowledge, Skills, Abilities

• Laboratory experience with molecular biology techniques (e.g., PCR, cloning, bacterial transformation).

• Experience with mammalian cell culture.

• Passion: A genuine interest in cellular engineering and the potential of CAR-T therapies.

• Familiarity with lentiviral production methods.

• Experience with sequencing analysis or flow cytometry.

We welcome applications from all backgrounds - diversity strengthens our team!

Ready to advance your protein sciences skills at the forefront of cell therapy? Apply today!

California Pay Transparency Disclosure:

Under the Federal Labor Standards Act, this position is classified non-exempt. The hourly rate range for 2024 Summer Internships is $25.00 to $35.00 per hour, not to exceed 40 hours per week. Compensation for this internship will be determined at the Company's sole discretion and may vary based on depth of relevant experience and education.

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What makes Metagenomi a unique place to work?

• We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating diseases.

• We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more!

• We offer competitive compensation, including a market-benchmarked salary, annual target bonus potential, equity, comprehensive benefits plan, 401(k) with company matching, retirement safe harbor plan, and other perks.

At Metagenomi, we know that our people drive our success. We are an equal opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law.

Applicants/Employees have rights under various State and Federal Employment Laws, including without limitation:

• Family & Medical Leave Act

• Equal Employment Opportunity Commission

• Employee Polygraph Protection Act

• California Family Rights Act

• California Fair Employment and Housing Act

Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi's Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.