Pfenex, a full-cycle biotechnology company engaged in the development of biosimilar medicines, is now pursuing novel protein therapeutics. We are committed to providing innovative solutions for global health. Our team is made up of driven, talent, motivated individuals making an immediate impact within our fast-paced dynamic organization.
Pfenex Drug Discovery Team is seeking a talented, enthusiastic, highly motivated drug hunter to contribute to preclinical research and drug discovery. The successful candidate will be a strategic member of a fast-paced and collaborative research group in discovering novel targets and leading preclinical research projects. The ideal candidate will contribute at the laboratory bench and manage 1-3 research scientists to drive Pfenex's preclinical research projects to IND stage.
ESSENTIAL DUTIES AND PRIMARY RESPONSIBILITIES
Leads hematologic malignancies drug discovery projects from early discovery to IND stage
Plans, designs, executes and troubleshooting of experiments to validate and to uncover novel biology of druggable targets
Performs experiments to identify lead molecules using cell biology, molecular biology and biochemistry techniques such as, but not limited to transfection, Western Blot, qPCR, ELISA, MSD, multi-color flow cytometry, protein expression and purification
Leads research scientists and associates to perform routine assays to support lead identification and optimization
Presents findings clearly and concisely to research teams to drive direction of drug discovery projects
Mentors and trains junior research scientists and associates
PhD in Immunology, Biochemistry, Molecular Biology, Cell Biology or related field in Biomedical Sciences
Minimum 5+ years of biotech/pharmaceutical industry experience is required
Demonstrated project leadership and contributions to R&D efforts that have led to the development of clinical candidates
Proficiency in protein expression and purification, cell-based in vitro assays, and a deep understanding of In Vivo pharmacology is required
Experience with primary cell culture, human or/and rodent blood is a plus
Have a broad experience in cellular and biological techniques including but not limited to Western Blot, qPCR, multi-color flow cytometry, MSD, HTRF, luminescence, confocal microscopy, live cell imaging
Experience in developing and optimizing cell-based assays using various assay platforms is required
Experience with liquid handling automation is desired
Extensive publication record in high-impact journal is desired
Proficiency in Microsoft Office, FlowJo, and GraphPad Prism; WinNonlin is a plus
Excellent organizational skills, able to multi-task and excited for hand-on laboratory research
Excellent oral and written communication skills
Must be a team player and perform at a high level in a matrixed drug discovery environment
Ability to train/ educate others
Level will be commensurate with experience
Affirmative Action and Equal Opportunity Employer (EOE).
Pfenex celebrates the diversity of life and welcomes all individuals to apply.
Must be legally authorized to work in the US without sponsorship