Principal Scientist, Translational Research

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

As a scientific leader in Biology, you will report into the Executive Director and Head of Cancer Pharmacology in Translational Research.

The responsibilities may include:

• Be a critical contributor and provide strong scientific and technical leadership in the translation research group with a focus on establishment, validation and characterization of complex preclinical disease models in vivo.

• Explore RAS inhibition as well as exploratory combinations in complex disease models.

• Work closely with scientists across different functions and projects in a matrix environment and serve as a functional rep in key project teams.

• Serve as key scientific liaison for external partnering and academic collaborations.

• Manage and analyze experimental data and present results at internal meetings and scientific conferences.

• Develop high-quality protocols and outputs and maintain detailed documentation of procedures and data to comply with internal standard operating procedures and other quality criteria, where necessary.

Required Education, Experience, and Skills:

• PhD. degree in pharmacology, oncology, cell biology or a related discipline, with at least 10 years of post-doctoral and relevant industry experience in cancer drug discovery and development.

• Rigorous, quantitative and detail-oriented experimentalist.

• Experience with gene editing via CRISPR and with GEMMs strongly desired.

• Strong track record of scientific productivity as evidenced by high-quality, impactful publications.

• Demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important.

• Excellent written and verbal communication skills.

• Thrives in a collaborative team setting and is driven by a desire to be innovative in a high energy, small company environment.

Preferred Skills, Experience and Education:

• Experience working with external collaborators on both preclinical animal models and ex vivo PD assays is preferred.

• Strategic thinker with deep understanding of oncology, prior project team leadership roles would be an advantage.

The expected salary range for this role is $195,000 to $245,000. An individual's position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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