Principal Scientist, Translational Medicine

The Principal Scientist, Translational Medicine, is a position within Translational Medicine & Early Clinical Development (TM-ECD) that partners with experts in the Discovery and Development functions to build effective biomarker strategies that will enable execution of biomarker-driven clinical development plans that support dose selection, biomarker proof-of-concept, and deep patient phenotyping. The ideal candidate will possess broad drug development expertise, coupled with deep knowledge of CNS disease biomarkers, and the ability to apply that expertise to the development of both small and large molecule neurodegenerative disease therapeutics.

Experience in biomarkers related to Frontotemporal Dementia is a plus. Key Accountabilities/Core Job Responsibilities: Perform research in a dynamic and collaborative environment.

Initiate/lead complex projects and collaborate cross-functionally and/or externally. Mentor more junior scientists in the lab and on project teams. Define biomarker strategies that can deliver clinical evidence of target engagement, pathway engagement and modulation of disease biomarkers in clinical development plans.

Design and implement biomarker assays in clinically relevant bio samples. Make detailed observations, analyze data, interpret and clearly communicate results in a variety of settings. Maintain timely and accurate lab records consistent with good documentation practices.

Significantly contribute to patent filings, diligence reports, primary research publications, and/or regulatory documents. Participate in top conferences and academic partnerships in the primary research area. Maintain excellent scientific expertise in primary research areas while expanding knowledge of related disciplines.

Can expect to spend up to 30% of their time in the lab. Qualifications/Skills: PhD is required with 7 years of industry and/or academic experience post-training.

Record of high-quality publications and/or public presentations focused on neurodegenerative disorders, neurobiology, translational research, and/or biomarkers. Demonstrated expertise in the development, execution and interpretation of complex biomarker assays. Excellent oral, presentation and written communication skills required.

Creative thinker with a strong sense of responsibility and a collaborative spirit. Outstanding time management skills across multiple projects. Salary Range: $158,000.00 - $206,780.00.

Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.