Principal Scientist, Primary Pharmacology Group

Pfizer Groton , MA 01450

Posted 6 months ago

ROLE SUMMARY

Pfizer colleagues have many perspectives, many backgrounds, and many strengths, but we share one goal: to improve the lives of patients. Worldwide Research and Development (WRD) combines research units that have deep disease area expertise with partner lines that deliver cutting-edge science, generating an efficient R&D operating model, to discover and develop innovative therapies. The successful candidate will join a team of ~50 scientists within the Primary Pharmacology Group (PPG) at our Groton, CT campus, focused on the design, development, and execution of in vitro plate-based screening assays supporting hit identification and lead optimization for small molecule drug discovery programs across Pfizer Research Units. Disease areas of focus for the group include Inflammation and Immunology, Cardiovascular/Metabolic, Rare Diseases, and Oncology. Working collaboratively with project teams, (s)he will lead the design and establishment of disease-relevant pharmacology strategies to both target-based and phenotypic programs, ensuring support from idea to clinical candidate selection.

Applicants must have experience working independently in a laboratory setting and a broad understanding of biology. Previous experience in 4 or more of the following is required: plate-based pharmacology, cell biology, biochemistry, enzymology, drug discovery, laboratory automation. Also critical to the role is a working knowledge of basic laboratory automation and data analysis softwares (e.g. ABase, GraphPad Prism, Spotfire). The successful candidate will be excited by working in teams with multiple partners (e.g. Chemistry, Research Unit Biology, Structural Biology, and CROs). The candidate should therefore possess strong collaborative and written/verbal communication skills and be adept at building partnerships. Key to the role is an ability to work independently and propose creative approaches for complex biological questions. As such, in addition to technical skills, (s)he should demonstrate a personal drive, leadership skills, flexibility/resiliency, and a good sense of humor.

At Pfizer, we believe in helping people lead healthier lives from our customers to our colleagues. We offer a wide array of programs and plans that give our colleagues the flexibility and tools they need to get and stay healthy, both physically and financially. These include competitive compensation, generous medical, vacation and retirement benefits as well as a number of additional programs.

The Primary Pharmacology Group offers a collegial and supportive environment for colleagues, with a culture encouraging openness, innovation and ownership of our science. We aim to provide scientific and growth opportunities for personal and career development commensurate with a colleague's goals and experience.

ROLE RESPONSIBILITIES

  • We seek a laboratory scientist to support hit identification and lead optimization for small molecule drugs discovery projects.

  • This scientist will play a key role in designing in vitro pharmacology strategies for target-based and phenotypic projects. (S)he will also design, optimize, and perform in vitro assays to drive lead identification and SAR using a combination of biochemical, target-based, and physiologically relevant assay systems. (S)he will carry out data analysis as well as review and interpret this data for project teams.

  • This person will be the lead representative from the Primary Pharmacology Group on project teams and may be asked to lead sub-teams on topics of relevance to the department.

  • This scientist will maintain a 'cutting edge' awareness of technical developments and scientific advancements in the field and apply these innovatively to advance internal capabilities. The role includes opportunities to publish when appropriate.

  • This scientist will work across an interdisciplinary team of Research Unit biologists, medicinal chemists, structural biologists and biophysicists, as well as external partners to deliver on the portfolio.

BASIC QUALIFICATIONS

  • PhD or equivalent with 5+ years of experience in biochemistry, cell biology, and/or pharmacology and 2+ years in plate-based pharmacology for drug discovery OR MS with 10+ years of relevant industry experience

  • Demonstrated experience with multiple in vitro assay formats (e.g. FRET, FACS, FP, ELISA, high content imaging, FLIPR, radioligand binding, etc.), including assay development and troubleshooting

  • Practical experience in cell culture, laboratory automation, and data analysis systems

  • Demonstration of excellent computer, verbal and written communication skills

PREFERRED QUALIFICATIONS

  • Previous experience in multiple target classes (e.g. GPCRs, transporters, kinases, ion channels,) in a drug discovery setting

  • Experience in functional genomics screening (siRNA, CRISPR)

  • Knowledge of associated disciplines such as molecular and cellular biology, protein chemistry, biophysical techniques and chemistry.

  • Demonstrated ability to forge strong collaborative relationships inside and outside organizational walls and across multiple cultures: academic, industrial, and CROs.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Other Job Details:

  • Eligible for Relocation Package

  • Eligible for Employee Referral Bonus

N (Other) (United States of America)

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.


icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon
lc_ad

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Principal Scientist Enzymology Dmpk

Pfizer

Posted 6 days ago

VIEW JOBS 11/8/2019 12:00:00 AM 2020-02-06T00:00 Role Summary Pfizer is seeking a dynamic and collaborative experimental scientist for a Principal Scientist position contributing to ADME (absorption, disposition, metabolism and excretion) sciences in the in vitro enzymology and preclinical pharmacokinetics (PK) group. The individual will be joining a dynamic group in ADME Sciences Enzymology, Department of Medicine Design, in support of the global Pfizer small molecule discovery research and development portfolio. The qualified candidate will be responsible for design, conduct and advancing in vitro enzymology, oversight of nonclinical pharmacokinetic studies, and/or modeling and simulation studies in support of ADME principles for programs. The individual will be a member of matrix teams comprised of other ADME discipline scientists and led by a project representative, with expectations that integrated information resolves ADME issues and advances programs. The role includes supervision and mentorship of laboratory staff, responsibility for experimental conduct or oversight, and resource management relevant to our therapeutic areas. The individual will also be expected to advance scientific understanding, grow effective partnerships externally as well as internally to incorporate growing technological advances, and incorporate novel experimental approaches to address challenging dispositional issues. Responsibilities * Provide scientific leadership and enzymology knowledge or expertise for lab-based portfolio support and scientific innovation relevant to ADME sciences.Relevant areas include understanding of drug clearance, tissue binding and disposition, reaction phenotyping, enzyme kinetics, enzyme inhibition/induction or relevant DDI data generation, and delivery or conduct of quality preliminary or definitive ADME studies in support of regulatory filings. * Working with modeling and simulation scientists, take scientific leadership for the predictions of clearance (IVIVE) and drug-drug interactions.This includes directing or undertaking physiologically based PK (PBPK) modeling strategies, which support and achieve project goals or address regulatory interactions. * Advise discovery and development project teams regarding approaches to understand and optimize dispositional attributes and to address any regulatory filings for clinical candidates. * Continue to build Pfizer's strong external network in PK and enzymology sciences to integrate advances at academic centers (eg tissue co-culture, MPS, tissue impairment) with our internal strategy and capabilities, and where appropriate, to progress precompetitive topics via collaborations and consortia. * Guide and develop laboratory-based scientists focused on the design and conduct of novel low- and medium-throughput in vitro assays to support discovery and definitive development assays for regulatory filings. * Review and approve DMPK study protocols, research reports, nonclinical ADME summaries, and abstracts/manuscripts for publication. * Direct original research aligned with the research priorities established by the Medicine Design Strategic Imperatives and Business Plan, as well as ongoing assay conduct to support the Pfizer discovery and development portfolio. * Proactively establish and grow effective partnerships externally as well as internally across multiple disciplines (e.g. Clinical Pharmacology, Pharmaceutical Sciences, Medicinal Chemistry, Computational Sciences, High Throughput Screening) to advance scientific innovation in the realm of ADME and to develop synergistic packages of scientific capabilities to support the portfolio. Basic Qualifications * PhD or equivalent with 2+ years of relevant postdoctoral academic or industry experience in the scientific field.Candidates with a diverse scientific background (eg pharmaceutical sciences, drug metabolism, pharmacokinetics, biochemistry, chemistry, biology, biomedical sciences, or engineering) are encouraged to apply. * A keen interest in growing knowledge and optimizing dispositional attributes of small molecules through ADME enzymology science and technology is required. * Experience working in matrix teams within and across technical/research line organizations, a collaborative problem solver. * Training in people and organizational leadership skills and supervisory skills. * Strong leadership and interpersonal skills as well as a track record of enthusiasm to deliver results in a fast-paced environment. * Highly effective written, presentation and verbal communication skills are essential. Preferred Qualifications * In-depth knowledge and experience in relevant areas of small molecule enzymology science and technology (eg phenotyping, competitive and/or time-dependent enzyme inhibition, induction, protein binding, tissue distribution, microsomal, hepatocyte and tissue fraction studies, or tissue culture). * ADME project representation or small molecule discovery and development experience. * Experience in pharmacokinetic data analysis (e.g. noncompartmental analysis), understanding of therapeutic exposure-effect relationships, and hands-on experience with physiologically-based (PBPK) modeling using tools such as Watson, Phoenix WinNonlin, Berkeley Madonna, MATLAB, and/or Simcyp is desirable. * Recognition for creativity and innovation through strong publication/presentation record. * Experience in advanced cell culture techniques such as co-culture or tissue engineering (eg MPS) experience is highly desirable. * Proficiency in the use of Microsoft Office Suite of tools (Outlook, Word, Excel, etc.) and hands-on experience establishing IVIVE, computational ADME predictions, and data visualization tools. Physical/Mental Requirements * Conduct of experiments will require the scientist to work in the laboratory, including standing, walking, sitting, and lifting solvents. Non-Standard Work Schedule, Travel or Environment Requirements * Periodic travel will be required to other Pfizer sites (eg Cambridge, MA; La Jolla, CA) or to attend and present at scientific conferences. #LI-PFE Other Job Details: * Eligible for Relocation Package * Eligible for Employee Referral Bonus Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates. Pfizer Groton MA

Principal Scientist, Primary Pharmacology Group

Pfizer