Principal Scientist, Molecular Discovery

Pfizer Cambridge , MA 02138

Posted 7 months ago


We are seeking a highly motivated scientist to join a display-based therapeutic antibody discovery group in the BioMedicine Design Department at Pfizer, Inc. in Cambridge, MA. The candidate will be responsible for design and construction of antibody display libraries and selection of primary hits and optimized leads for biotherapeutic programs using phage and yeast display technologies. The role requires a strong background in molecular biology, phage or yeast display, assay development and high- throughput screening. An understanding of antibody structure and experience with NextGen sequencing are strongly desired. The successful candidate should demonstrate a strong passion for life science and an ability to thrive in a fast-paced collaborative environment.


  • Design and construct antibody libraries for optimization of affinity and manufacturability properties.

  • Develop high-throughput technologies for rapid antibody discovery and optimization.

  • Design and execute antibody discovery campaigns using phage and yeast display technology.

  • Develop assays and execute high-throughput antibody screening using robotic liquid handling equipment.

  • Analyze selection outcomes and identify hits using next-generation sequencing (NGS).

  • Characterize IgGs by analytical techniques such as ELISA, flow cytometry, and Octet.

  • Independently analyze data and troubleshoot methods. Present experimental design and assay results at internal meetings


  • PhD in molecular biology/immunology/cell biology or a related discipline with a minimum of 5 years of research experience

  • Strong molecular biology skills, including at least 3 years of hands-on experience with primer design, PCR, and antibody library design and construction.

  • Minimum of 3 years' experience using phage or yeast display technology for antibody isolation.

  • Minimum of 2 years' experience in development and execution of screening assays, including ELISA, HTRF, and flow cytometry.

  • Strong computational skills:minimumof 2 years' experience in analysis of large antibody sequence and screening data sets, development of automation protocols, protein structural analysis, etc.

  • Strong communication skills and ability to present research in a team setting.


  • Experience with sample preparation for NGS and NGS data analysis strongly preferred.

  • Experience with using liquid handling and imaging automation and designing automated high-throughput screening protocols strongly preferred.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Other Job Details

  • Eligible for Relocation Package: yes

  • Eligible for Employee Referral


Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

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Principal Scientist, Molecular Discovery