Principal Scientist

Johnson & Johnson San Diego , CA 92140

Posted 1 week ago

Janssen Research and Development, a member of Johnson and Johnson Family of Companies, is recruiting for a Principal Scientist to be located in San Diego, CA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.

Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit for more information.

We are Janssen. Our mission drives us.

Our patients inspire us. We collaborate with the world for the health of everyone in it.

Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.

The successful candidate will support drug discovery and early development efforts as a member of the DMPK team. The candidate will serve as a site and global expert on biotransformation for both small and large molecule drugs to optimize discovery chemistry, mitigate safety risks from unfavorable metabolic pathways, and understand the metabolic fate of development candidates.

The candidate will work closely with discovery team medicinal chemists and DMPK project team representatives on metabolism related questions to provide mechanistic insight, offer solutions to shape team strategy, and guide research critical for team decision-making. In addition, the candidate will foster the development of junior biotransformation scientists, indoctrinating both the technical and scientific skill-sets required of the drug metabolism field. Additional responsibilities will include conducting and leading innovative research in the field and shaping global biotransformation strategy.


  • The successful candidate will have a PhD with 8+ years of relevant industry experience utilizing LC/MS/MS and NMR data to localize sites of metabolism.

  • The successful candidate will have a long-track record supporting drug metabolism studies and an extensive publication record.

  • The candidate must possess a strong medicinal chemistry background as well as expertise using high resolution mass spectrometers and NMR and their associated software's to support biotransformation work (TOFs, Q-Traps, Orbitraps etc.).

  • In addition, the candidate must have a strong understanding of DMPK principles and their application to drug discovery and early development phase.

  • Excellent interpersonal, organizational, oral/written communication and teamwork skills are required.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Primary Location

United States-California-San Diego-


Janssen Research & Development, LLC (6084)

Job Function


Requisition ID

icon no score

See how you match
to the job

Find your dream job anywhere
with the LiveCareer app.
Mobile App Icon
Download the
LiveCareer app and find
your dream job anywhere
App Store Icon Google Play Icon

Boost your job search productivity with our
free Chrome Extension!

lc_apply_tool GET EXTENSION

Similar Jobs

Want to see jobs matched to your resume? Upload One Now! Remove
Principal Scientist

Mirati Therapeutics, Inc

Posted 2 months ago

VIEW JOBS 10/21/2019 12:00:00 AM 2020-01-19T00:00 What is this role really like? The Drug Discovery team at Mirati is responsible for the invention, optimization and characterization of quality small molecules as clinical candidates for Mirati research programs. The Principal Scientist will be responsible for medicinal chemistry strategy, compound design, synthesis and compound progression activities enabling advancement of oncology drug discovery programs. Key efforts will be directed at the invention, preparation, and characterization of compounds as potential new targeted anticancer drug candidates; the advancement of compounds through hit-to-lead, lead optimization and candidate selection activities, and initiation of new projects by identifying viable starting points for chemistry activities. Experience with structure-based drug design and optimizing lead compounds within a drug discovery program is desired. Day-to-Day Duties: * Lead a drug discovery project from early stage through candidate selection. * Drive medicinal chemistry and lead optimization strategies as a key member of drug discovery teams. * Optimize compound delivery and synthetic efficiency, primarily utilizing FTE and fee-for-service based CROs. Maintain effective communication with CROs (email; teleconferences; web meetings), visiting key CROs as necessary. Contribute to building a productive, internal Mirati chemistry lab. * Contribute novel IP as a key member of drug discovery teams. * Coordinate compound progression activities with outside partners and CROs * Maintain corporate database; prepare and deliver internal presentations, patent applications and external publications as driven by the project and corporate strategies. Requirements: * Ph.D with 3+ years of experience in a relevant chemistry discipline in a laboratory environment with synthetic organic chemistry and drug discovery background * Relevant experience in a synthetic/medicinal chemistry laboratory, with pharmaceutical or biotech industry experience preferred * A proven track record of experience and expertise in synthetic chemistry, medicinal chemistry and drug discovery. Demonstrated experience in advancing lead compounds through preclinical discovery stages to candidate selection preferred * Strong understanding of key components and processes of drug discovery * Experience with Fragment-based drug discovery, Structure-based drug discovery, fundamentals of cheminformatics, and Property-based drug design preferred * Demonstration of outstanding communication skills through internal and external presentations and publications EOE Mirati Therapeutics, Inc San Diego CA

Principal Scientist

Johnson & Johnson