Principal Scientist, Immunology

(San Diego, CA) Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases.

Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA. Summary We seek a motivated, detail-oriented Principal Scientist with strong background in translational immunology / cell biology and experience developing cell-based assays to support our efforts in target validation, early phase antibody drug discovery, IND-enabling studies, biomarker discovery and companion diagnostics development. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment, with a demonstrated ability to work collaboratively to support project goals and objectives.

Responsibilities Lead or co-lead biological drug-discovery programs, with an emphasis in clinical lead generation. Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification and/or companion diagnostics development. Analyze, critically interpret data and share results to project teams as required.

Keep meticulous records of experiments performed. Act as a resource for other scientists in the group. Qualifications PhD, MD or equivalent post-graduate degree in Immunology or related field with 8 years or more of experience in academia and industry, preferably in the field of auto-immune diseases.

Prior industry experience in translational immunology is a plus. Prior experience managing Associates/Scientists. Prior experience leading project teams and managing CROs/vendors.

Direct experience working with immunology, inflammation and immune-mediated fibrotic diseases (Skin, Gut or Lung) or relevant molecular pathways. Hands-on lab experience in an industry drug discovery / development setting a plus. Strong knowledge functional assay development, experience with preclinical animal models of autoimmune disease and ex-vivo models to assess immune responses in human (and other animal species) whole blood, PBMCs and various primary cell subsets required.

Experience using multi-color flow cytometry to immunophenotype human cells from blood and tissues preferred as is hands-on experience using MSD, Luminex or ELISA to measure analytes in serum, plasma, supernatant or cell lysates is required. Proficient with MS office and standard data analysis packages (e.g. Prism, Flowjo, Systat). Self-motivated with excellent problem-solving, organizational and communication skills.

The expected base pay range for this position is $150,000 – $225,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class. Apply