Located in Boulder, CO, Pfizer Boulder (formerly Array Biopharma) is currently seeking a highly motivated and team-oriented candidate for the position of Sr. Research Scientist, in the Drug Metabolism and Pharmacokinetics (DMPK) department. The successful candidate will support ADME/PK activities on one or more discovery project teams, facilitating the identification and development of small molecule cancer therapeutics.
Serve as DMPK subject matter expert on cross-functional teams, providing in vitro and in vivo drug disposition data, interpretation, and presentations
Assist in the design and coordination of in vivo PK studies in laboratory animals
Develop LC-MS/MS methods and perform bioanalysis for in vitro and in vivo biological samples
Perform PK data analysis and interpret results in relation to in vivo ADME data and PK data from compound analogs
Design and conduct in vitro experiments in liver microsomes or hepatocytes to generate compound metabolites, characterize metabolic pathways, evaluate metabolism kinetics, determine bioactivation mechanisms, etc.
Identify metabolites from mass spectral data and further characterize potentially active or reactive metabolites
Provide guidance on chemical modifications that may improve ADME properties
Prepare documents for regulatory IND filings
Ph.D. in pharmacokinetics, drug metabolism, biochemistry, chemistry or other relevant fields
5 years of relevant industry experience
Fundamental understanding of various DMPK areas such as physicochemical properties, PK, drug metabolizing enzyme and transporter kinetics, and mechanisms of bioactivation
Hands-on experience and strong trouble shooting skills for LC-MS/MS bioanalysis
Experience interpreting mass spectral data to make structural assignments
WinNonlin/Phoenix experience preferred
Excellent oral and written communication skills
Excellent interpersonal skills and ability to work in a team environment
Ideal candidate will have experience managing a small team of DMPK scientists
ADDITIONAL OFFER DETAILS
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Research and Development