Principal Scientist, Downstream Process Development

Radiometer Westborough , MA 01580

Posted 2 months ago

Pall Corporation of Westborough is seeking a Principal Scientist, Downstream Process Development. Pall's Process Development Services group provides our customers with best in class, innovative solutions for their downstream processing needs.

You will be a subject matter expert (SME) on manufacturing downstream processes for gene therapy and biologic applications working with new game changing technologies as well as provide scientific leadership to a small team of purification scientists reporting to the PDS lab Senior Manager. We are a fun, dedicated, hardworking, science driven organization, if this sounds like you, apply today!

Responsibilities include:

  • Mentoring, executing, developing, providing guidance and managing workloads for the associates and being part of the hands on purification team.

  • Lead planning and execution of experiments for Pall downstream process development services including, depth filtration, chromatography I, polish chromatography TFF testing, sterile filtration, AKTA systems, or other DSP automation systems

  • Prepare project reports, by combining all data from a specific project from multiple individuals and making recommendations to clients on the direction of the project

  • Close interaction with the customer, presenting rational behind the experiment plan and experimental results

  • Prepare detailed protocols for execution for practical work and batch manufacturing records for process transfer to GMP manufacturing

  • Assist the project manager with administrative functions preparation of report drafts, budget tracking, draft proposals, BoM

  • Plan and execute experiments for DSP, experience with process development and scale-up of DSP unit-operations

  • Troubleshoot customer data, look for efficiencies and recommend right products and equipment to achieve best results

  • Train and support DSP activities in Portsmouth, UK PDS Lab

  • Perform analytical assays, possibly including gels, ELISA, qPCR, SDS-Page

  • Analyze project results and summarize for discussion with team. Make recommendations for further optimization

  • Bachelors in biological science / chemical engineering & minimum of 7 years of experience in protein purification or MS in biology / chemical engineering & 5 years of experience in protein purification or a PhD with 3 industrial relevant purification experience

  • Experience with purification with chromatography strength of viral particles (gene therapy and/or vaccine fields) or Monoclonal antibodies

  • Small scale purification development as well as large scale experience

  • A good understanding of product purification mechanisms

  • Prior experience compiling information into technical reports

  • Supervisory experience including performance management and development of employees

  • Ability to travel as needed.

Diversity & Inclusion

At Danaher, we are dedicated to building and sustaining a truly diverse and inclusive culture. These are not just words on a page

Diversity and Inclusion is a top priority for the company, and it ties deeply to each of our core values. Danaher Corporation and all Danaher Companies are equal opportunity employers that evaluate applicants without regard to race, color, national origin, religion, sex, age, marital status, disability, veteran status, sexual orientation, gender identity, or other characteristics protected by law.


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Principal Scientist, Downstream Process Development

Radiometer